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Collateral status affects the onset-to-reperfusion time window for good outcome

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Author(s)
Byung Moon KimJang-Hyun BaekJi Hoe HeoHyo Suk NamYoung Dae KimJoonsang YooDong Joon KimPyoung JeonSeung Kug BaikSang Hyun SuhKyung Yol LeeHyo Sung KwakHong Gee RohYoung-Jun LeeSang Heum KimChang-Woo RyuYon-Kwon IhnByungjoon Kim Hong Jun Jeon,17 Jin Woo Kim,18 Jun Soo Byun,19 Sangil Suh,20 Jeong Jin Park,21 Woong Jae Lee,22 Jieun Roh,6 Byoung-Soo Shin,23 Oh Young Bang24
Keimyung Author(s)
Yoo, Joon Sang
Department
Dept. of Neurology (신경과학)
Journal Title
J Neurol Neurosurg Psychiatry
Issued Date
2018
Volume
89
Issue
9
Abstract
Objective
To characterise the time window in which endovasc lar thrombectomy (EVT) is associated with good outcome, and to test the differential relationship between functional outcome and onset-to-reperfusion time (ORT), depending on collateral status.

Methods
This was a retrospective analysis of clinical and imaging data of 554 consecutive patients, who had recanalisation success by EVT for anterior circulation large artery occlusion, from the prospectively maintained registries of 16 comprehensive stroke centres between September 2010 and December 2015. The patients were dichotomised into good and poor collateral groups, based on CT angiography. We tested whether the likelihood of good outcome (modified Rankin Scale, 0–2) by ORT was different between two groups.

Results
ORT was 298 min±113 min (range, 81–665 min), and 84.5% of patients had good collaterals. Age, diabetes mellitus, previous infarction, National Institutes of Health Stroke Scale, good collaterals (OR 40.766; 95% C I 10.668 to 155.78; p<0.001) and ORT (OR 0.926 every 30 min delay; 95% C I 0.862 to 0.995; p=0.037) were independently associated with good outcome. The drop in likelihood of good outcome associated with longer ORT was significantly faster in poor collateral group (OR 0.305 for every 30 min; 95% C I 0.113 to 0.822) than in good collateral group (OR 0.926 for every 30 min; 95% C I 0.875 to 0.980).

Conclusions
Earlier successful recanalisation was strongly associated with good outcome in poor collateral group; however, this association was weak during the tested time window in good collateral group. This suggests that the ORT window for good outcome can be adjusted according to collateral status.
Keimyung Author(s)(Kor)
유준상
Publisher
School of Medicine (의과대학)
Citation
Byung Moon Kim et al. (2018). Collateral status affects the onset-to-reperfusion time window for good outcome. J Neurol Neurosurg Psychiatry, 89(9), 903–909. doi: 10.1136/jnnp-2017-31762
Type
Article
ISSN
1468-330X
Source
https://jnnp.bmj.com/content/89/9/903.long
DOI
10.1136/jnnp-2017-31762
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41696
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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