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Multi-institutional study of treatment patterns in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study

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Author(s)
Taeryool KooDo Hoon LimHo Jun SeolChul‑Kee ParkIl Han KimJong Hee ChangJeongshim LeeShin JungHo‑Shin GwakKwan Ho ChoChang‑Ki HongIk Jae LeeEl KimJin Hee KimYong‑Kil HongHong Seok JangChae‑Yong KimIn Ah KimSung Hwan KimYoung Il KimEun‑Young KimWoo Chul KimSemie Hong
Keimyung Author(s)
Kim, ElKim, Jin Hee
Department
Dept. of Neurosurgery (신경외과학)
Dept. of Radiation Oncology (방사선종양학)
Journal Title
J Neurooncol.
Issued Date
2018
Volume
138
Issue
3
Keyword
Patterns of careLow-grade gliomaRadiotherapyPCVTemozolomide
Abstract
Introduction
We performed this study to identify the treatment patterns of patients with low-grade gliomas (LGG) in Korea.

Methods A total of 555 patients diagnosed as WHO grade II gliomas between 2000 and 2010 at 14 Korean institutions were included. The patients were divided into four adjuvant treatment groups: adjuvant fractionated radiotherapy (RT, N = 204), adjuvant chemotherapy (N = 20), adjuvant fractionated RT and chemotherapy (N = 65), and non-adjuvant treatment (N = 266) groups. We examined differences among the groups and validated patient/tumor characteristics associated with the adjuvant treatments.

Results
Astrocytoma was diagnosed in 210 patients (38%), oligoastrocytoma in 85 patients (15%), and oligodendroglioma in 260 patients (47%). Gross total resection was performed in 200 patients (36%), subtotal resection in 153 (28%), partial resection in 71 patients (13%), and biopsy in 131 patients (24%). RT was most commonly applied as an adjuvant treatment. The use of chemotherapy with or without RT decreased after 2008 (from 38 to 4%). The major chemotherapeutic regimen was procarbazine, lomustine, and vincristine (PCV); however, the proportion of temozolomide increased since 2005 (up to 69%). Patient/tumor characteristics related with RT were male gender, non-seizure, multiple lobes involvement, and nongross total resection. Chemotherapy was associated with non-gross total resection and non-astrocytoma.

Conclusions
A preference for RT and increased use of temozolomide was evident in the treatment pattern of LGG. The extent of resection was associated with a decision to perform RT and chemotherapy. To establish a robust guideline for LGG, further studies including molecular information are needed.
Keimyung Author(s)(Kor)
김 엘
김진희
Publisher
School of Medicine (의과대학)
Citation
Taeryool Koo et al. (2018). Multi-institutional study of treatment patterns in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study. J Neurooncol., 138(3), 667–677. doi: 10.1007/s11060-018-2839-z
Type
Article
ISSN
1573-7373
Source
https://link.springer.com/article/10.1007%2Fs11060-018-2839-z
DOI
10.1007/s11060-018-2839-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41701
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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