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Nicorandil reduces burn wound progression by enhancing skin blood flow

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Author(s)
Jaehoon ChoiRyeolwoo KimJunhyung KimWoonhyeok JeongSang Woo ParkHyoun Wook LeeHo Yun Chung
Keimyung Author(s)
Choi, Jae HoonKim, Jun HyungJeong, Woon Hyeok
Department
Dept. of Plastic Surgery (성형외과학)
Journal Title
Journal of Plastic, Reconstructive & Aesthetic Surgery
Issued Date
2018
Volume
71
Issue
8
Keyword
NicorandilZone of stasisComb burnBurn wound progression
Abstract
We assessed whether nicorandil, an adenosine triphosphate–sensitive K + channel opener, reduces burn wound progression in a rat comb burn model. A total of 24 rats were used. Following thermal injury, one dose of nicorandil (10 or 30 mg/kg) was administered intra- gastrically twice daily for 3 days. At days 1 and 3 after injury, skin was harvested for histopatho- logical examination and protein isolation. Rats treated with the 10-mg/kg and 30-mg/kg doses of nicorandil exhibited significantly increased tissue survival in the zone of stasis at days 1 and 3 after injury. The 10-mg/kg and 30-mg/kg nicorandil doses also significantly increased skin perfusion in the zone of stasis at days 1 and 3 after injury. At 30 mg/kg, nicorandil significantly reduced hypoxia-inducible factor-1 αexpression in the zone of stasis at day 1 after injury and reduced inflammatory responses in the zone of stasis. The latter effect included decreased polymorphonuclear neutrophil leukocyte infiltration and interleukin-1 βrelease at day 1 after injury. At 30 mg/kg, nicorandil also significantly reduced expression of nuclear factor- κB p65, akey transcriptional factor in the regulation of inflammatory mediators, in the zone of stasis at day 1 after injury. Our study demonstrates that a 30 mg/kg dosing schedule of nicorandil increases tissue survival in the zone of stasis by attenuating ischemia–reperfusion injury. This effect is mediated by the enhancement of skin blood flow and reduction in the inflammatory response. Therefore, our findings suggest that nicorandil has potential clinical applications for patients with burns.
Keimyung Author(s)(Kor)
최재훈
김렬우
김준형
정운혁
Publisher
School of Medicine (의과대학)
Citation
Jaehoon Choi et al. (2018). Nicorandil reduces burn wound progression by enhancing skin blood flow. Journal of Plastic, Reconstructive & Aesthetic Surgery, 71(8), 1196–1206. doi: 10.1016/j.bjps.2018.03.020
Type
Article
ISSN
1878-0539
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1748681518301232?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1748681518301232%3Fshowall%3Dtrue&referrer=https:%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F%3Fterm%3D29748072
DOI
10.1016/j.bjps.2018.03.020
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41713
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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