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Disease Activity Patterns Recorded Using a Mobile Monitoring System Are Associated with Clinical Outcomes of Patients with Crohn’s Disease

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Author(s)
Eun Soo KimSung Kook KimByung Ik JangKyeong Ok KimEun Young KimYoo Jin LeeHyun Seok LeeSang Gyu Kwak
Keimyung Author(s)
Kim, Eun SooLee, Yoo Jin
Department
Dept. of Internal Medicine (내과학)
Journal Title
Digestive Diseases and Sciences
Issued Date
2018
Volume
63
Issue
9
Keyword
Crohn’s diseaseDisease activity patternSmartphone
Abstract
Background
Usefulness of a mobile monitoring system for Crohn’s disease (CD) has not been evaluated. We aimed to determine whether disease activity patterns depicted using a web-based symptom diary for CD could indicate disease clinical outcomes.

Methods
Patients with CD from tertiary hospitals were prospectively invited to record their symptoms using a smartphone at least once a week. Disease activity patterns for at least 2 months were statistically classified into good and poor groups based on two factors in two consecutive time frames; the degree of score variation (maximum–minimum) in each frame and the trend (upward, stationary, or downward) of patterns indicated by the difference in the mean activity scores between two time frames.

Results
Overall, 220 (82.7%) and 46 (17.3%) patients were included in good and poor groups, respectively. Poor group was significantly more associated with disease-related hospitalization (p = 0.004), unscheduled hospital visits (p = 0.005), and bowel surgery (p < 0.001) during the follow-up period than good group. In the multivariate analysis, poor patterns [odds ratio (OR) 2.62, p = 0.006], stricturing (OR 4.19, p < 0.001) or penetrating behavior (OR 2.27, p = 0.012), and young age at diagnosis (OR 1.06, p = 0.019) were independently associated with disease-related hospitalization. Poor patterns (OR 4.06, p = 0.006) and an ileal location (OR 5.79, p = 0.032) remained independent risk factors for unscheduled visits. Poor patterns (OR 15.2, p < 0.001) and stricturing behavior (OR 9.77, p = 0.004) were independent risk factors for bowel surgery.

Conclusion
The disease activity patterns depicted using a web-based symptom diary were useful indicators of poor clinical outcomes in patients with CD.
Keimyung Author(s)(Kor)
김은수
이유진
Publisher
School of Medicine (의과대학)
Citation
Eun Soo Kim et al. (2018). Disease Activity Patterns Recorded Using a Mobile Monitoring System Are Associated with Clinical Outcomes of Patients with Crohn’s Disease. Digestive Diseases and Sciences, 63(9), 2220–2230. doi: 10.1007/s10620-018-5110-8
Type
Article
ISSN
1573-2568
Source
https://link.springer.com/article/10.1007%2Fs10620-018-5110-8
DOI
10.1007/s10620-018-5110-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41715
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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