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Comparison of acoustic radiation force impulse elastography and transient elastography for prediction of hepatocellular carcinoma recurrence after radiofrequency ablation

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Author(s)
Jun Sik YoonYu Rim LeeYoung-Oh KweonWon Young TakSe Young JangSoo Young ParkKeun HurJung Gil ParkHye Won LeeJae Min ChunYoung Seok HanWon Kee Lee
Keimyung Author(s)
Lee, Hye Won
Department
Dept. of Pathology (병리학)
Journal Title
European Journal of Gastroenterology & Hepatology
Issued Date
2018
Volume
30
Issue
10
Keyword
catheter ablationcarcinomahepatocellularelasticity imagingtechniquesliver cirrhosisrecurrence
Abstract
Background
To compare the clinical value of acoustic radiation force impulse (ARFI) elastography and transient elastography (TE) for hepatocellular carcinoma (HCC) recurrence prediction after radiofrequency ablation (RFA) and to investigate other predictors of HCC recurrence.

Patients and methods
Between 2011 and 2016, 130 patients with HCC who underwent ARFI elastography and TE within 6 months before curative RFA were prospectively enrolled. Independent predictors of HCC recurrence were analyzed separately using ARFI elastography and TE. ARFI elastography and TE accuracy to predict HCC recurrence was determined by receiver operating characteristic curve analysis.

Results
Of all included patients (91 men; mean age, 63.5 years; range: 43–84 years), 51 (42.5%) experienced HCC recurrence during the follow-up period (median, 21.9 months). In multivariable analysis using ARFI velocity, serum albumin and ARFI velocity [hazard ratios: 2.873; 95% confidence interval (CI): 1.806–4.571; P< 0.001] were independent predictors of recurrence, and in multivariable analysis using TE value, serum albumin and TE value (hazard ratios: 1.028; 95% CI: 1.013–1.043; P< 0.001) were independent predictors of recurrence. The area under the receiver operating characteristic curve of ARFI elastography (0.821; 95% CI: 0.747–0.895) was not statistically different from that of TE (0.793; 95% CI: 0.712–0.874) for predicting HCC recurrence (P=0.827). The optimal ARFI velocity and TE cutoff values were 1.6 m/s and 14 kPa, respectively.

Conclusion
ARFI elastography and TE yield comparable predictors of HCC recurrence after RFA. Eur J Gastroenterol Hepatol 30:1230–1236
Keimyung Author(s)(Kor)
이혜원
Publisher
School of Medicine (의과대학)
Citation
Jun Sik Yoon et al. (2018). Comparison of acoustic radiation force impulse elastography and transient elastography for prediction of hepatocellular carcinoma recurrence after radiofrequency ablation. European Journal of Gastroenterology & Hepatology, 30(10), 1230–1236. doi: 10.1097/MEG.0000000000001170
Type
Article
ISSN
1473-5687
Source
https://insights.ovid.com/pubmed?pmid=29794814
DOI
10.1097/MEG.0000000000001170
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41718
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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