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Safety and Effectiveness of Peramivir in Korean Adult Influenza Patients: Prospective Observational Study Based on Post-Marketing Surveillance Data

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Author(s)
Taekgeun OhkKi Ho ParkJin-Won ChungDoo Ryeon ChungDong Kee KimSang-Rok LeePill Young KimShin-Woo KimJi Yun NohWon Suk ChoiSeong Yeol RyuJacob LeeSang-Bum HongJoong Sik EomJonghwan ShinJoon Young SongHee Jin CheongWoo Joo Kim
Keimyung Author(s)
Ryu, Seong Yeol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean medical science
Issued Date
2018
Volume
33
Issue
32
Keyword
InfluenzaAntiviralPeramivirSafetyEffectivenessClinical Trial
Abstract
Background:
The safety and clinical effectiveness data of peramivir in the real clinical field are limited. A prospective observational study was conducted based on the post-marketing surveillance data to evaluate the post-marketing safety and effectiveness of peramivir in Korean adults with seasonal influenza.

Methods:
Among adults aged 20 years or older who were diagnosed with influenza A or B, patients who started peramivir within 48 hours from the initial symptoms of influenza were enrolled. All adverse events (AEs) that occurred within 7 days after administration of peramivir were checked. For the evaluation of effectiveness, changes in the severity of influenza symptoms and daily living performance were examined before and 7 days after the administration of peramivir. The date on which influenza related symptoms disappeared was checked.

Results:
A total of 3,024 patients were enrolled for safety evaluation and 2,939 patients were for effectiveness evaluation. In the safety evaluation, 42AEs were observed in 35 (1.16%) patients. The most common AE was fever. AEs were mostly rated as mild in severity. Serious AEs were observed in 10 patients and two of them died. However, both deaths were considered to be less relevant to peramivir. In the effectiveness evaluation, the severity of influenza symptoms decreased by 10.68 ± 4.01 points and daily living performance was improved 5.59 ± 2.16 points. Influenza related symptoms disappeared on average 3.02 ± 2.39 days after peramivir administration.
Keimyung Author(s)(Kor)
류성열
Publisher
School of Medicine (의과대학)
Citation
Taekgeun Ohk et al. (2018). Safety and Effectiveness of Peramivir in Korean Adult Influenza Patients: Prospective Observational Study Based on Post-Marketing Surveillance Data. Journal of Korean medical science, 33(32), e212–e212. doi: 10.3346/jkms.2018.33.e212
Type
Article
ISSN
1598-6357
Source
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070467/
DOI
10.3346/jkms.2018.33.e212
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41749
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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