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A feasibility study of laparoscopic total gastrectomy for clinical stage I gastric cancer: a prospective multi-center phase II clinical trial, KLASS 03

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Author(s)
Sung Jin OhWoo Jin HyungHan‑Kwang YangSang‑Uk HanYoung‑Jun LeeJoong‑Min ParkJin Jo KimOh Kyung KwonSeong Ho KongHyoung‑Il KimHyuk‑Joon LeeWook KimSeung Wan RyuSung‑Ho JinKeun Won RyuMin‑Chan KimHye‑Seong AhnYoung Kyu ParkYoung‑Ho KimSun‑Hwi HwangJong Won KimGyu Seok Cho
Keimyung Author(s)
Ryu, Seung Wan
Department
Dept. of Surgery (외과학)
Journal Title
Gastric Cancer
Issued Date
2019
Volume
22
Issue
1
Keyword
Gastric cancerLaparoscopyTotal gastrectomy
Abstract
Background
With improved short-term surgical outcomes, laparoscopic distal gastrectomy has rapidly gained popularity. However, the safety and feasibility of laparoscopic total gastrectomy (LTG) has not yet been proven due to the difficulty of the technique. This single-arm prospective multi-center study was conducted to evaluate the use of LTG for clinical stage I gastric cancer.

Methods
Between October 2012 and January 2014, 170 patients with pathologically proven, clinical stage I gastric adenocarcinoma located at the proximal stomach were enrolled. Twenty-two experienced surgeons from 19 institutions participated in this clinical trial. The primary end point was the incidence of postoperative morbidity and mortality at postoperative 30 days. The severity of postoperative complications was categorized according to Clavien–Dindo classification, and the incidence of postoperative morbidity and mortality was compared with that in a historical control.

Results
Of the enrolled patients, 160 met criteria for inclusion in the full analysis set. Postoperative morbidity and mortality rates reached 20.6% (33/160) and 0.6% (1/160), respectively. Fifteen patients (9.4%) had grade III or higher complications, and three reoperations (1.9%) were performed. The incidence of morbidity after LTG in this trial did not significantly differ from that reported in a previous study for open total gastrectomy (18%).

Conclusions
LTG performed by experienced surgeons showed acceptable postoperative morbidity and mortality for patients with clinical stage I gastric cancer.
Keimyung Author(s)(Kor)
류승완
Publisher
School of Medicine (의과대학)
Citation
Sung Jin Oh et al. (2019). A feasibility study of laparoscopic total gastrectomy for clinical stage I gastric cancer: a prospective multi-center phase II clinical trial, KLASS 03. Gastric Cancer, 22(1), 214–222. doi: 10.1007/s10120-018-0864-4
Type
Article
ISSN
1436-3305
Source
https://link.springer.com/article/10.1007%2Fs10120-018-0864-4
DOI
10.1007/s10120-018-0864-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41761
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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