계명대학교 의학도서관 Repository

Prevalence and risk factors for upper gastrointestinal diseases in health check-up subjects: a nationwide multicenter study in Korea.

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Author(s)
Kwangwoo NamJeong Eun ShinSung Eun KimGwang Ho BaikSang Hyeon ChoiJu Yup LeedKyung Sik ParkYoung-Eun JooDae-Seong MyungHyeon Ju KimHyun Joo SongSuck Chei ChoiHyun Jin KimHyun Young KimNayoung Kim
Keimyung Author(s)
Lee, Ju YupPark, Kyung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
Scandinavian Journal of Gastroenterology
Issued Date
2018
Volume
53
Issue
8
Keyword
Gastric cancerHelicobacter pylorihealth check-uppeptic ulcer diseasereflux esophagitis
Abstract
Objectives:
The prevalence of upper gastrointestinal disease is expected to change following advances in socioeconomic status and improved hygiene in Korea. The aim of this study was to investigate the recent trends in upper gastrointestinal diseases based on endoscopic findings and Helicobacter pylori (H. pylori) seroprevalence in subjects undergoing health check-up at tertiary centers in Korea.

Methods:
A multicenter cross-sectional study was conducted at nine healthcare centers between September 2016 and June 2017. The subjects were evaluated using questionnaires, upper endoscopy and H. pylori serology tests. The results were compared with previous data in our study group obtained from eight tertiary healthcare centers in 2011 (n ¼ 4023).

Results:
In total, we prospectively enrolled 2504 subjects undergoing health check-up. The prevalence of reflux esophagitis (RE) was 9.7%, which showed an increasing but insignificant trend since 2011 (8.8%). The prevalence of active and healing-stage benign gastric ulcer and duodenal ulcer (DU) was 1.6% and 1.2%, respectively, which confirmed a significant decrease since 2011 (4.1%; p < .001 and 2.2%; p ¼ .005, respectively). The prevalence of gastric cancer was 0.5%, representing an increasing trend since 2011 (0.12%; p ¼ .003). H. pylori seroprevalence was 51.3%, which significantly decreased from 2011 (59.8%; p < .001). In multivariate analysis, H. pylori seropositivity was a significant risk factor for DU (p < .001), whereas a significant protective factor against RE (p < .001).

Conclusions:
The significant decrease of H. pylori seroprevalence in the past five years altered the incidence of upper gastrointestinal disease.
Keimyung Author(s)(Kor)
이주엽
박경식
Publisher
School of Medicine (의과대학)
Citation
Kwangwoo Nam et al. (2018). Prevalence and risk factors for upper gastrointestinal diseases in health check-up subjects: a nationwide multicenter study in Korea. Scandinavian Journal of Gastroenterology, 53(8), 910–916. doi: 10.1080/00365521.2018.1487992
Type
Article
ISSN
1502-7708
Source
https://www.tandfonline.com/doi/full/10.1080/00365521.2018.1487992
DOI
10.1080/00365521.2018.1487992
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41767
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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