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Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma

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Author(s)
Jun Sik YoonGyeonghwa KimYu Rim LeeSoo Young ParkYoung-Oh KweonWon Young TakJung Gil ParkHye Won LeeYoung Seok HanHeon Tak HaJae Min ChunSe Young JangKeun Hur
Keimyung Author(s)
Lee, Hye Won
Department
Dept. of Pathology (병리학)
Journal Title
Biomarkers in Medicine
Issued Date
2018
Volume
12
Issue
10
Keyword
disease progressionhepatocellular carcinomamicroRNA-21microRNA-31prognosissurvivaltherapeutics
Abstract
Aim:
Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC).

Materials & methods:
Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression.

Results:
MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage.

Conclusion:
Elevated miR-21 expression might represent a biomarker for HCC prognosis.
Keimyung Author(s)(Kor)
이혜원
Publisher
School of Medicine (의과대학)
Citation
Jun Sik Yoon et al. (2018). Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma. Biomarkers in Medicine, 12(10), 1105–1114. doi: 10.2217/bmm-2018-0096
Type
Article
ISSN
1752-0371
Source
https://www.futuremedicine.com/doi/abs/10.2217/bmm-2018-0096
DOI
10.2217/bmm-2018-0096
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41770
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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