Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma
- Keimyung Author(s)
- Lee, Hye Won
- Department
- Dept. of Pathology (병리학)
- Journal Title
- Biomarkers in Medicine
- Issued Date
- 2018
- Volume
- 12
- Issue
- 10
- Keyword
- disease progression; hepatocellular carcinoma; microRNA-21; microRNA-31; prognosis; survival; therapeutics
- Abstract
- Aim:
Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC).
Materials & methods:
Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression.
Results:
MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage.
Conclusion:
Elevated miR-21 expression might represent a biomarker for HCC prognosis.
- Keimyung Author(s)(Kor)
- 이혜원
- Publisher
- School of Medicine (의과대학)
- Citation
- Jun Sik Yoon et al. (2018). Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma. Biomarkers in Medicine, 12(10), 1105–1114. doi: 10.2217/bmm-2018-0096
- Type
- Article
- ISSN
- 1752-0371
- Source
- https://www.futuremedicine.com/doi/abs/10.2217/bmm-2018-0096
- Appears in Collections:
- 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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