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Association between white matter lesions and cerebral Aβ burden

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Author(s)
Hyon-Ah YiKyoung Sook WonHyuk Won ChangHae Won Kim
Keimyung Author(s)
Yi, Hyon AhWon, Kyoung SookKim, Hae Won
Department
Dept. of Neurology (신경과학)
Dept. of Nuclear Medicine (핵의학)
Journal Title
PLoS One
Issued Date
2018
Volume
13
Issue
9
Abstract
Introduction
White matter lesions (WMLs), detected as hyperintensities on T2-weighted MRI, represent small vessel disease in the brain and are considered a potential risk factor for memory and cognitive impairment in older adults. The purpose of this study was to evaluate the association between WMLs and cerebral amyloid-β (Aβ) burden in patients with cognitive impairment.

Methods
A total of 83 patients with cognitive impairment, who underwent brain MRI and F-18 florbetaben PET, were included prospectively: 19 patients were cognitively unimpaired, 30 exhibited mild cognitive impairment (MCI), and 34 exhibited dementia. The Fazekas scale was used to quantify WMLs on T2-weighted brain MR images. Cerebral Aβ burden was quantitatively estimated using volume-of-interest analysis. Differences in cerebral Aβ burden were evaluated between low-WML (Fazekas scale 1) and high-WML (Fazekas scale 2) groups. The relationship between the Fazekas rating and cerebral Aβ burden was evaluated using linear regression analysis after adjusting for age and sex.

Results
In the overall cohort, the high-WML group exhibited significantly higher Aβ burden compared with the low-WML group (P = 0.011) and cerebral Aβ burden was positively correlated with Fazekas rating (β = 0.299, P = 0.006). In patients with MCI, the high-WML group exhibited significantly higher Aβ burden compared with the low-WML group (P = 0.019) and cerebral Aβ burden was positively correlated with Fazekas rating (β = 0.517, P = 0.003).

Conclusion
The presence of WMLs was associated with cerebral Aβ burden in patients with MCI. Our findings suggest that small vessel disease in the brain is related to Alzheimer's disease pathology.
Keimyung Author(s)(Kor)
이현아
원경숙
김해원
Publisher
School of Medicine (의과대학)
Citation
Hyon-Ah Yi et al. (2018). Association between white matter lesions and cerebral Aβ burden. PLoS One, 13(9), e0204313–e0204313. doi: 10.1371/journal.pone.0204313
Type
Article
ISSN
1932-6203
Source
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204313
DOI
10.1371/journal.pone.0204313
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41783
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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