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Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer

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Author(s)
SUNG UK BAEWOON KYUNG JEONGSEONG KYU BAEKNAM KYU KIMILSEON HWANG
Keimyung Author(s)
Bae, Sung UkJeong, Woon KyungBaek, Seong KyuHwang, Il Seon
Department
Dept. of Surgery (외과학)
Dept. of Pathology (병리학)
Journal Title
Oncology Letters
Issued Date
2018
Volume
16
Issue
4
Keyword
colorectal neoplasmsprogrammed cell death 1 receptorprognosissurvival analysis
Abstract
The present study evaluated the association between programmed cell death ligand‑1 (PD‑L1) expression and long‑term oncologic outcomes in colorectal cancer (CRC). PD‑L1 expression was evaluated using immunohistochemistry in 175 patients who underwent surgical resection for CRC between September 1999 and August 2004. Patients were grouped according to PD‑L1 expression, with 82 (46.9%) and 93 (53.1%) in the low and high PD‑L1 expression groups, respectively. The overall survival (OS) and disease‑free survival (DFS) rates were significantly better in the high expression group compared with in the low expression group (OS: 48.2 vs. 32.9%, P=0.047; DFS: 43.3 vs. 32.9%, P=0.021). According to the Tumor‑Node‑Metastasis stage subgroups, the OS rates in the low and high expression groups, respectively, were 66.7 and 60.0% in stage I (P=0.715), 51.8 and 46.7% in stage II (P=0.789), 19.6 and 51.1% in stage III (P=0.011) and 9.1 and 0% in stage IV (P=0.005). The DFS rates in the low and high expression groups, respectively, were 66.7 and 60.0% in stage I (P=0.715), 51.8 and 46.7% in stage II (P=0.857), 19.6 and 38.3% in stage III (P=0.006) and 9.1 and 0% in stage IV (P=0.700). The systemic recurrence rate was significantly higher in the low expression group compared with in the high expression group (42.7 vs. 12.9%, respectively, P=0.030). Low PD‑L1 expression was significantly associated with tumor relapse and poor prognosis in stage III CRC.
Keimyung Author(s)(Kor)
배성욱
정운경
백성규
황일선
Publisher
School of Medicine (의과대학)
Citation
SUNG UK BAE et al. (2018). Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer. Oncology Letters, 16(4), 5214–5222. doi: 10.3892/ol.2018.9264
Type
Article
ISSN
1792-1082
Source
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144363/
DOI
10.3892/ol.2018.9264
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41785
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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