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Clinical significance of the Kidney Donor Profile Index in deceased donors for prediction of post-transplant clinical outcomes: A multicenter cohort study

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Author(s)
Jong Hoon LeeWoo Yeong ParkYoung Soo KimBum Soon ChoiCheol Whee ParkChul Woo YangYong-Soo KimKyubok JinSeungyeup HanByung Ha Chung
Keimyung Author(s)
Park, Woo YoungJin, Kyu BokHan, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
PLoS One
Issued Date
2018
Volume
13
Issue
10
Abstract
Background
We investigated whether the Kidney Donor Profile Index (KDPI) system is useful in predicting clinical outcomes in deceased donor kidney transplantation (DDKT).

Methods
Four hundred sixty-nine kidney transplant recipients (KTRs) receiving kidneys from 359 deceased donors were included in this study, which involved three transplant centers. KTRs were divided into high and low KDPI KTR groups based on the median KDPI score of 67%. We compared clinical outcomes between the high KDPI and low KDPI groups.

Results
There were no significant differences in the incidence of delayed graft function and acute rejection between high and low KDPI KTR groups. In comparison with histologic findings in allograft tissues obtained within three months from KT, the proportion of glomerulosclerosis was significantly higher in the high KDPI KTR group than in the low KDPI KTR group. With Kaplan-Meier analysis, the graft survival rate was significantly lower in the high KDPI KTR group than in the low KDPI KTR group (Log rank, P = 0.017), and multivariate analysis also demonstrated that a high KDPI score was a significant risk factor for death censored allograft failure (HR 2.62, 95% CI, 1.29±5.33, P = 0.008).

Conclusion
The KDPI scoring system is useful in predicting allograft outcomes in a Korean DDKT cohort.
Keimyung Author(s)(Kor)
박우영
진규복
한승엽
Publisher
School of Medicine (의과대학)
Citation
Jong Hoon Lee et al. (2018). Clinical significance of the Kidney Donor Profile Index in deceased donors for prediction of post-transplant clinical outcomes: A multicenter cohort study. PLoS One, 13(10), e0205011–e0205011. doi: 10.1371/journal.pone.0205011
Type
Article
ISSN
1932-6203
Source
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205011
DOI
10.1371/journal.pone.0205011
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41793
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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