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A cross-sectional retrospective study to analyze the underlying causes and clinical characteristics of children with reactive thrombocytosis at a Korean tertiary medical center

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Author(s)
Juhee ShinDong Hyun LeeNani JungHee Joung ChoiYe Jee Shim
Keimyung Author(s)
Jung, Nan IChoi, Hee JoungShim, Ye Jee
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Blood Research
Issued Date
2018
Volume
53
Issue
3
Keyword
Reactive thrombocytosisExtreme thrombocytosisChildrenEtiologyKawasaki disease
Abstract
Background
Reactive thrombocytosis (RT) is a common condition among children, although no studies have examined the etiology or clinical characteristics of RT among Korean children.

Methods
This retrospective study evaluated children with RT at a single Korean tertiary center during a 10-year period.

Results
RT accounted for 13.5% of children who were admitted to the pediatric ward (4,113/30,355): mild RT, 82.7%; moderate RT, 14.1%; severe RT, 1.1%; and extreme RT, 2.1%. There was a negative correlation between platelet count and Hb level (P=0.008). There were positive correlations between platelet count and WBC (P=0.001), erythrocyte sedimentation rate (ESR) (P=0.007), and admission duration (P=0.006). The most common cause of RT was infection and the second most common was Kawasaki disease (KD). The highest proportion of lower respiratory tract infection was observed in extreme RT (P<0.001). The proportion of KD was highest in extreme RT (P<0.001) and in children aged 1‒7.9 years (P<0.001). The proportion of refractory KD was highest in extreme RT (P=0.005). In cases of KD, there was a positive correlation between platelet count and fever duration (P=0.006). Non-KD autoimmune inflammation was only observed in mild/moderate RT, and its proportion was highest in children aged 8‒18 years (P<0.001).

Conclusion
In children, more severe RT was associated with lower Hb, increased WBC, ESR, and prolonged admission. With respiratory infection or KD, extreme RT was associated with more severe disease course.
Keimyung Author(s)(Kor)
정난이
최희정
심예지
Publisher
School of Medicine (의과대학)
Citation
Juhee Shin et al. (2018). A cross-sectional retrospective study to analyze the underlying causes and clinical characteristics of children with reactive thrombocytosis at a Korean tertiary medical center. Blood Research, 53(3), 233–239. doi: 10.5045/br.2018.53.3.233
Type
Article
ISSN
2288-0011
Source
http://www.bloodresearch.or.kr/journal/view.html?volume=53&number=3&spage=233
DOI
10.5045/br.2018.53.3.233
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41803
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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