Trends in the seroprevalence of Helicobacter pylori infection and its putative eradication rate over 18 years in Korea: A cross-sectional nationwide multicenter study
- Author(s)
- Hyun Jin Kim; Jeong Yoon Yim; Joo Sung Kim; Seon Hee Lim; Nayoung Kim; Jin Won Kwon; Sung Eun Kim; Gwang Ho Baik; Ju Yup Lee; Kyung Sik Park; Jeong Eun Shin; Hyun Joo Song; Dae-Seong Myung; Suck Chei Choi
- Keimyung Author(s)
- Lee, Ju Yup; Park, Kyung Sik
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- PLoS One
- Issued Date
- 2018
- Volume
- 18
- Issue
- 10
- Abstract
- The aims of this study were to demonstrate the trends in seropositivity and the eradication therapy rate for Helicobacter pylori (H. pylori) over an 18-year period in an asymptomatic Korean population and to explore the factors associated with H. pylori seropositivity and its eradication therapy. In total, 23,770 subjects (aged 17±97 years) from a health examination center participated in this cross-sectional study from January 2016 to June 2017. Questionnaires that included questions about the participants' H. pylori eradication therapy history were collected, and anti-H. pylori IgG antibodies were measured. Among the eligible subjects, the seroprevalence of H. pylori infection was 41.5%. The H. pylori eradication therapy rate increased continuously from 2005 (13.9%) to 2011 (19.3%) and then increased again until the first half of 2017 (23.5%) (P < 0.001). After exclusion of subjects with a history of gastric surgery, gastric cancer, H. pylori eradication therapy, or gastric symptoms, H. pylori seropositivity was 43.9% in 16,885 subjects, which was significantly lower than the seropositivities in 1998 (66.9%), 2005 (59.6%), and 2011 (54.4%). The risk factors associated with H. pylori seropositivity according to multivariable analysis were male sex (odds ratio (OR) 1.34, 95% confidence interval (CI): 1.23±1.46), medium educational level (OR 1.17, 95% CI: 1.05±1.31), medium household income level (OR 1.10, 95% CI: 1.03±1.19), and age of 60±69 years (OR 8.78, 95% CI: 6.41±11.85). The observed downward trend in H. pylori seroprevalence and increase in H. pylori eradication over the 18-year period will affect upper gastrointestinal disorders in South Korea.
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