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Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era (from KAMIR-NIH registry)

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Author(s)
Dae-Won KimSung-Ho HerHa Wook ParkKiyuk ChangWook Sung ChungKi Bae SeungMyung Ho JeongHyo-Soo KimHyeon Cheol GwonIn Whan SeongKyung Kuk HwangShung Chull ChaeKwon-Bae KimYoung Jo KimKwang Soo ChaSeok Kyu OhJei Keon ChaeJi-Hoon Jung
Keimyung Author(s)
Kim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Geriatric Cardiology
Issued Date
2018
Volume
15
Issue
9
Keyword
Acute myocardial infarctionAged-populationMajor adverse cardiocerebrovascular events
Abstract
Objectives
To evaluate the age-related one-year major adverse cardiocerebrovascular events (MACCE) after percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI). We analyzed the association between age and one-year MACCE after AMI.

Methods
A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institue of Health (KAMIR-NIH) between November 2011 and December 2015 were classified into four groups according to age (Group I, < 60 years, n = 4199; Group II, 6070 years, n = 2577; Group III; 7080 years, n = 2774; Group IV, 80 years, n = 1018). Patients were analyzed for one-year composite of MACCE (cardiac death, myocardial infarction, target vessel revascularization, cerebrovascular events) after AMI.

Results
The one-year MACCE in AMI were 3.5% (Group I), 6.3% (Group II), 9.6% (Group III) and 17.6% (Group IV). After adjustment for confounding parameters, the analysis results showed that patients with AMI had incremental risk of one-year MACCE [Group II, adjusted hazard ratios (aHR) = 1.224, 95% CI: 0.9651.525, P = 0.096; Group III, aHR = 1.316, 95% CI: 1.0371.671, P = 0.024; Group IV, aHR = 1.975, 95% CI: 1.50062.601, P < 0.001) compared to Group I. Especially, cardiac death in the composite of primary end point played a major role in this effect (Group II, aHR = 1.335, 95% CI: 0.9411.895, P = 0.106; Group III, aHR = 1.575, 95% CI: 1.1222.210, P = 0.009; Group IV, aHR = 2.803, 95% CI: 1.9374.054, P < 0.001).

Conclusions
Despite advanced techniques and medications for PCI in AMI, age still exerts a powerful influence in clinical outcomes. Careful approaches, even in the modern era of developed cardiology are needed for aged-population in AMI intervention.
Keimyung Author(s)(Kor)
김권배
Publisher
School of Medicine (의과대학)
Citation
Dae-Won Kim et al. (2018). Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era (from KAMIR-NIH registry). Journal of Geriatric Cardiology, 15(9), 574–584. doi: 10.11909/j.issn.1671-5411.2018.09.005
Type
Article
Source
http://www.jgc301.com/ch/reader/view_abstract.aspx?file_no=20180111001&flag=1
DOI
10.11909/j.issn.1671-5411.2018.09.005
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41811
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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