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SREBP1c-PAX4 Axis Mediates Pancreatic β-Cell Compensatory Responses Upon Metabolic Stress

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Author(s)
Gung LeeHagoon JangYe Young KimSung Sik ChoeJinuk KongInjae HwangJeu ParkSeung-Soon ImJae Bum Kim
Keimyung Author(s)
Im, Seung Soon
Department
Dept. of Physiology (생리학)
Journal Title
Diabetes
Issued Date
2019
Volume
68
Issue
1
Abstract
Sterol responsive element-binding protein 1c (SREBP1c) is a key transcription factor for de novo lipogenesis. Although SREBP1c is expressed in pancreatic islets, its physiological roles in pancreatic β cells are largely unknown. In this study, we demonstrate that SREBP1c regulates β cell compensation under metabolic stress. SREBP1c expression level was augmented in pancreatic islets from obese and diabetic animals. In pancreatic β cells, SREBP1c activation promoted the expression of cell cycle genes and stimulated β cell proliferation through its novel target gene, PAX4. Compared to SREBP1c+/+ mice, SREBP1c– /– mice showed glucose intolerance with low insulin levels. Moreover, β cells from SREBP1c– /– mice exhibited reduced capacity to proliferate and secrete insulin. Conversely, transplantation of SREBP1c overexpressing islets restored insulin levels and relieved hyperglycemia in streptozotocin-induced diabetic animals. ollectively, these data suggest that pancreatic SREBP1c is a key player in mediating β cell compensatory responses in obesity.
Keimyung Author(s)(Kor)
임승순
Publisher
School of Medicine (의과대학)
Citation
Gung Lee et al. (2019). SREBP1c-PAX4 Axis Mediates Pancreatic β-Cell Compensatory Responses Upon Metabolic Stress. Diabetes, 68(1), 81–94. doi: 10.2337/db18-0556
Type
Article
ISSN
1939-327X
Source
https://diabetes.diabetesjournals.org/content/68/1/81.long
DOI
10.2337/db18-0556
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41813
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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