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The prognostic factors influencing overall survival in uterine cervical cancer with brain metastasis

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Author(s)
Hyera KimKang Kook LeeMi Hwa HeoJin Young Kim
Keimyung Author(s)
Lee, Kang KookHeo, Mi HwaKim, Jin Young
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Journal of Internal Medicine
Issued Date
2018
Keyword
Brain metastasisUterine cervical neoplasmsPrognosis
Abstract
Background/Aims:
The occurrence of brain metastasis (BM) has increased due to improved overall survival (OS) in uterine cervical cancer. However, research about prognostic factors and therapeutic guidelines for BM in uterine cervical cancer remains scarce due to the rarity of BM in this type of cancer. The present study evaluated the clinical characteristics and prognostic factors influencing OS in patients with BM from uterine cervical cancer.

Methods:
A total of 19 BM patients of uterine cervical cancer were analyzed retrospectively from January 1995 to December 2016.

Results:
The median and mean OS of all patients was 9.6 and 15.4 months. Treatment (vs. palliative care, p < 0.001), fewer than three regimens of chemotherapy before BM (vs. ≥ 3, p < 0.013), and chemotherapy after BM (vs. absence, p < 0.001) significantly increased the OS time. The Karnofsky performance status ≥ 70 (vs. <70, p = 0.213), single BM (vs. multiple BM, p = 0.157), and small cell carcinoma (vs. others, p = 0.351) had numerically higher OS than others. Dual therapy (vs. single therapy, p = 0.182; vs. no therapy, p = 0.076) were associated with a longer OS time, but the difference did not reach statistical significance. In addition, the graded prognostic assessment (GPA) appeared to be a better prognostic tool than the recursive partitioning analysis.

Conclusions:
The results of the present study suggest active multimodal treatment including neurosurgery, radiotherapy, and chemotherapy for BM of uterine cervical cancer with single BM, good performance status, histology of small cell carcinoma, and a better GPA.
Keimyung Author(s)(Kor)
이강국
허미화
김진영
Publisher
School of Medicine (의과대학)
Citation
Hyera Kim et al. (2018). The prognostic factors influencing overall survival in uterine cervical cancer with brain metastasis. Korean Journal of Internal Medicine. doi: 10.3904/kjim.2018.051
Type
Article
ISSN
2005-6648
Source
http://kjim.org/journal/view.php?doi=10.3904/kjim.2018.051
DOI
10.3904/kjim.2018.051
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41816
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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