계명대학교 의학도서관 Repository

Quality of Anticoagulation and Treatment Satisfaction in Patients with Non-Valvular Atrial Fibrillation Treated with Vitamin K Antagonist: Result from the KORean Atrial Fibrillation Investigation II

Metadata Downloads
Author(s)
Seil OhJune-Soo KimYong-Seog OhDong-Gu ShinHui-Nam PakGyo-Seung HwangKee-Joon ChoiJin-Bae KimMan-Young LeeHyung-Wook ParkDae-Kyeong KimEun-Sun JinJaeseok ParkIl-Young OhDae-Hee ShinHyoung-Seob ParkJun Hyung KimNam-Ho KimMin-Soo AhnBo-Jeong SeoYoung-Joo KimSeongsik KangJuneyoung LeeYoung-Hoon Kim
Keimyung Author(s)
Park, Hyoung Seob
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2018
Volume
33
Issue
49
Keyword
Atrial FibrillationAnticoagulationVitamin K AntagonistINR ControlSatisfaction
Abstract
Background:
Vitamin K antagonist (VKA) to prevent thromboembolism in non-valvular atrial fibrillation (NVAF) patients has limitations such as drug interaction. This study investigated the clinical characteristics of Korean patients treated with VKA for stroke prevention and assessed quality of VKA therapy and treatment satisfaction.

Methods:
We conducted a multicenter, prospective, non-interventional study. Patients with CHADS2 ≥ 1 and treated with VKA (started within the last 3 months) were enrolled from April 2013 to March 2014. Demographic and clinical features including risk factors of stroke and VKA treatment information was collected at baseline. Treatment patterns and international normalized ratio (INR) level were evaluated during follow-up. Time in therapeutic range (TTR) > 60% indicated well-controlled INR. Treatment satisfaction on the VKA use was measured by Treatment Satisfaction Questionnaire for Medication (TSQM) after 3 months of follow-up.

Results:
A total of 877 patients (age, 67; male, 60%) were enrolled and followed up for one year. More than half of patients (56%) had CHADS2 ≥ 2 and 83.6% had CHA2DS2-VASc ≥ 2. A total of 852 patients had one or more INR measurement during their follow-up period. Among those patients, 25.5% discontinued VKA treatment during follow-up. Of all patients, 626 patients (73%) had poor-controlled INR (TTR < 60%) measure. Patients' treatment satisfaction measured with TSQM was 55.6 in global satisfaction domain.

Conclusion:
INR was poorly controlled in Korean NVAF patients treated with VKA. VKA users also showed low treatment satisfaction.
Keimyung Author(s)(Kor)
박형섭
Publisher
School of Medicine (의과대학)
Citation
Seil Oh et al. (2018). Quality of Anticoagulation and Treatment Satisfaction in Patients with Non-Valvular Atrial Fibrillation Treated with Vitamin K Antagonist: Result from the KORean Atrial Fibrillation Investigation II. Journal of Korean Medical Science, 33(49), e323–e323. doi: 10.3346/jkms.2018.33.e323
Type
Article
ISSN
1598-6357
Source
https://jkms.org/DOIx.php?id=10.3346/jkms.2018.33.e323
DOI
10.3346/jkms.2018.33.e323
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41832
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.