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Optimal surgical treatment in patients with T1b gallbladder cancer:An international multicenter study

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Author(s)
Hyeong Seok KimJae Woo ParkHongbeom KimYoungmin HanWooil KwonSun-Whe KimYoon Jin HwangSang Geol KimHyung Ju n KwonEduardo VinuelaNicolas JarufeJuan Carlos RoaIn Woong HanJin Seok HeoSeong-Ho ChoiDong Wook ChoiKeun Soo AhnKoo Jeong KangWoohyung LeeChi-Young JeongSoon-Chan HongAndres TroncosoHector LosadaSung-Sik HanSang-Jae ParkHiroaki YanagimotoItaru EndoKeiichi KubotaToshifumi WakaiTetsuo AjikiNazmi Volkan AdsayJin-Young Jang
Keimyung Author(s)
Ahn, Keun SooKang, Koo Jeong
Department
Dept. of Surgery (외과학)
Journal Title
Journal of Hepato-Biliary-Pancreatic Sciences
Issued Date
2018
Volume
25
Issue
12
Keyword
CholecystectomyExtendedGallbladder cancerLaparoscopiccholecystectomySimple
Abstract
Background
There is no consensus on the optimal treatment of T1b gallbladdercancer (GBC) due to the lack of evidence and the difficulty of anatomy andpathological standardization.

Methods
A total of 272 patients with T1b GBC who underwent surgical resection at 14centers with specialized hepatobiliary-pancreatic surgeons and pathologists in Korea,Japan, Chile, and the United States were studied. Clinical outcomes including disease-specific survival (DSS) rates according to the types of surgery were analyzed.

Results
After excluding patients, the 237 qualifying patients consisted of 90 men and 147women. Simple cholecystectomy (SC) was performed in 116 patients (48.9%) andextended cholecystectomy (EC) in 121 patients (51.1%). The overall 5-year DSS was94.6%, and it was similar between SC and EC patients (93.7% vs. 95.5%, P = 0.496). The5-year DSS was similar between SC and EC patients in America (82.3% vs. 100.0%,P = 0.249) as well as in Asia (98.6% vs. 95.2%, P = 0.690). The 5-year DSS also did notdiffer according to lymph node metastasis (P = 0.688) or tumor location (P = 0.474).

Conclusions
SC showed similar clinical outcom es (including recurrence) and survivaloutcomes as EC; therefore, EC is not needed for the treatmen t of T1b GBC.
Keimyung Author(s)(Kor)
안근수
강구정
Publisher
School of Medicine (의과대학)
Citation
Hyeong Seok Kim et al. (2018). Optimal surgical treatment in patients with T1b gallbladder cancer:An international multicenter study. Journal of Hepato-Biliary-Pancreatic Sciences, 25(12), 533–543. doi: 10.1002/jhbp.593
Type
Article
ISSN
1868-6982
Source
https://onlinelibrary.wiley.com/doi/full/10.1002/jhbp.593
DOI
10.1002/jhbp.593
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41846
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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