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Dietary intake of pantothenic acid is associated with cerebral amyloid burden in patients with cognitive impairment

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Author(s)
Jae-Ho LeeSoo-Yeon AnnHyon Ah LeeKyoung Sook WonHyuk Won ChangJungsu S. OhHae Won Kim
Keimyung Author(s)
Lee, Jae HoYi, Hyon AhWon, Kyoung Sook
Department
Dept. of Anatomy (해부학)
Dept. of Neurology (신경과학)
Dept. of Nuclear Medicine (핵의학)
Journal Title
Food & Nutrition Research
Issued Date
2018
Volume
62
Keyword
Alzheimer’s diseasemild cognitive impairmentpantothenic acidsubjective cognitive impairmentvitamindiet
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the deposition of amyloid-β pep-tide (Aβ) in diffuse and neuritic plaques. Previous research has suggested that certain vitamins may pre-vent this process. In the present study, we evaluated the relationship between vitamin intake and cerebral Aβ burden in patients with cognitive impairment. This study included 19 patients with subjective cogni-tive impairment and 30 patients with mild cognitive impairment. All patients underwent brain MRI and 18 F-florbetaben positron emission tomography. The Food Frequency Questionnaire was used to evalu-ate dietary intake of the 15 vitamins. Intake of vitamin B6 (p = 0.027), vitamin K (p = 0.042), vitamin A(p = 0.063), riboflavin (p = 0.063), β-carotene (p = 0.081), pantothenic acid (p = 0.092), and niacin (p = 0.097) was higher in the Aβ-positive group than in the Aβ-negative group. Multivariate linear regression analysis revealed that pantothenic acid intake was an independent determinant of cerebral Aβ burden (β= 0.287, p= 0.029). No significant correlations were observed between cerebral Aβ burden and the intake of other vitamins. Our findings demonstrated that pantothenic acid intake may be associated with increased cerebral Aβ burden in patients with cognitive impairment. These results may offer insight into potential strategies for AD prevention.
Keimyung Author(s)(Kor)
이재호
이현아
원경숙
Publisher
School of Medicine (의과대학)
Citation
Jae-Ho Lee et al. (2018). Dietary intake of pantothenic acid is associated with cerebral amyloid burden in patients with cognitive impairment. Food & Nutrition Research, 62, 1415–1415. doi: 10.29219/fnr.v62.1415
Type
Article
ISSN
1654-661X
Source
https://foodandnutritionresearch.net/index.php/fnr/article/view/1415
DOI
10.29219/fnr.v62.1415
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41848
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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