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Female Gender is a Poor Predictive Factor of Functional Dyspepsia Resolution after Helicobacter pylori Eradication: A Prospective, Multi-center Korean Trial

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Author(s)
Sung Eun KimNayoung KimSeon Mee ParkWon Hee KimGwang Ho BaikYunju JoKyung Sik ParkJu Yup LeeKi-Nam ShimGwang Ha KimBong Eun LeeSu Jin HongSeon-Young ParkSuck Chei ChoiJung Hwan OhHyun Jin Kim
Keimyung Author(s)
Lee, Ju Yup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Journal of Gastroenterology
Issued Date
2018
Volume
72
Issue
6
Keyword
Helicobacter pyloriDyspepsiaFemaleSymptom assessment
Abstract
Background/Aims:
The predictive factors of functional dyspepsia (FD) remain controversial. Therefore, we sought to investigate symptom responses in FD patients after Helicobacter pylori (H. pylori) eradication and used predictive factor analysis to identify significant factors of FD resolution at one-year after commencing eradication therapy.

Methods:
This prospective, multi-center clinical trial was performed on 65 FD patients that met Rome III criteria and had H. pylori infection. Symptom responses and factors that predicted poor response were determined by analysis one year after commencing H. pylori eradication therapy.

Results:
A total of 63 patients completed the one-year follow-up. When an eradication success group (n=60) and an eradication failure group (n=3) were compared with respect to FD response rate at one year, results were as follows; complete response 73.3% and 0.0%, satisfactory response 1.7% and 0.0%, partial response 10.0% and 33.3%, and refractory response 15.0% and 66.7%, respectively (p=0.013). Univariate analysis showed persistent H. pylori infection (p=0.021), female gender (p=0.025), and medication for FD during the study period (p=0.013) were associated with poor FD response at one year. However, age, smoking, alcohol consumption, and underlying disease were not found to affect response. Finally, multivariate analysis showed that female gender (OR, 4.70; 95% CI, 1.17-18.88) was the sole independent risk factor of poor FD response at one year after commencing H. pylori eradication therapy.

Conclusions:
Female gender was found to predict poor response in FD patients despite H. pylori eradication. Furthermore, successful H. pylori eradication appears to be associated with FD improvement, but the number of non-eradicated patients was too small to conclude.
Alternative Title
기능성 소화불량증 환자에서 헬리코박터 파일로리 제균 치료 효과 및 관련 요인: 국내 전향적, 다기관 연구
Keimyung Author(s)(Kor)
이주엽
Publisher
School of Medicine (의과대학)
Citation
Sung Eun Kim et al. (2018). Female Gender is a Poor Predictive Factor of Functional Dyspepsia Resolution after Helicobacter pylori Eradication: A Prospective, Multi-center Korean Trial. Korean Journal of Gastroenterology, 72(6), 286–294. doi: 10.4166/kjg.2018.72.6.286
Type
Article
ISSN
2233-6869
Source
http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2018.72.6.286
DOI
10.4166/kjg.2018.72.6.286
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41853
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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