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Prospective Validation of the Korean Cancer Study Group Geriatric Score (KG)-7, a Novel Geriatric Screening Tool, in Older Patients with Advanced Cancer Undergoing First-line Palliative Chemotherapy

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Author(s)
Jin Won KimSe Hyun KimYun-Gyoo LeeIn Gyu HwangJin Young KimSu-Jin KohYoon Ho KoSeong Hoon ShinIn Sook WooSoojung HongTae-Yong KimJi Yeon BaekHyun Jung KimHyo Jung KimMyung Ah LeeJung Hye KwonYong Sang HongHun-Mo RyooKyung Hee LeeJee Hyun Kim
Keimyung Author(s)
Kim, Jin Young
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancer Research and Treatment
Issued Date
2019
Volume
51
Issue
3
Keyword
Geriatric assessmentKG-7Screening toolsProspectiveValidation
Abstract
Purpose
The purpose of this study was to prospectively validate the Korean Cancer Study Group Geriatric Score (KG)-7, a novel geriatric screening tool, in older patients with advanced cancer planned to undergo first-line palliative chemotherapy.

Materials and Methods
Participants answered the KG-7 questionnaire before undergoing geriatric assessment (GA) and first-line palliative chemotherapy. The performance of KG-7 was evaluated by calculating the sensitivity (SE), specificity (SP), positive and negative predictive value (PPV and NPV), balanced accuracy (BA), and area under the curve (AUC).

Results
The baseline GA and KG-7 results were collected from 301 patients. The median age was 75 years (range, 70 to 93 years). Abnormal GA was documented in 222 patients (73.8%). Based on the ! 5 cut-off value of KG-7 for abnormal GA, abnormal KG-7 score was shown in 200 patients (66.4%). KG-7 showed SE, SP, PPV, NPV, and BA of 75.7%, 59.7%, 84.4%, 46.0%, and 67.7%, respectively; AUC was 0.745 (95% confidence interval, 0.687 to 0.803). Furthermore, patients with higher KG-7 scores showed significantly longer survival (p= 0.006).

Conclusion
KG-7 appears to be adequate in identifying patients with abnormal GA prospectively. Hence, KG-7 can be a useful screening tool for Asian countries with limited resources and high patient volume.
Keimyung Author(s)(Kor)
김진영
Publisher
School of Medicine (의과대학)
Citation
Jin Won Kim et al. (2019). Prospective Validation of the Korean Cancer Study Group Geriatric Score (KG)-7, a Novel Geriatric Screening Tool, in Older Patients with Advanced Cancer Undergoing First-line Palliative Chemotherapy. Cancer Research and Treatment, 51(3), 1249–1256. doi: 10.4143/crt.2018.451
Type
Article
ISSN
2005-9256
Source
https://www.e-crt.org/journal/view.php?doi=10.4143/crt.2018.451#
DOI
10.4143/crt.2018.451
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41911
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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