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Influence of anti-tumor necrosis factor-alpha therapy on pregnant women with inflammatory bowel disease and their children’s immunity

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Author(s)
Ko Eun LeeSung-Ae JungSang Hyoung ParkChang Mo MoonSo Yeon ShimEun Soo KimSu Jin ChoSeong-Eun KimKwang Bum ChoSuk-Kyun Yang
Keimyung Author(s)
Kim, Eun SooCho, Kwang Bum
Department
Dept. of Internal Medicine (내과학)
Journal Title
Intestinal Research
Issued Date
2019
Volume
17
Issue
2
Keyword
Inflammatory bowel diseaseAnti-tumor necrosis factor alphaPregnancy outcomeImmunityAnti-HBs antibody
Abstract
Background/Aims:
The onset of inflammatory bowel disease (IBD) usually occurs at young age, and therefore, women IBD patients experience pregnancy during their disease progression. Recently, the use of anti-tumor necrosis factor-α (anti-TNF-α) has been rapidly increasing. The aim of this study was to evaluate pregnancy related outcomes in women with IBD who were treated with anti-TNF-α during pregnancy and immunity of their children.

Methods:
Korean women with IBD who had been treated with anti-TNF-α during pregnancy had been enrolled. Medical records were reviewed and a survey was performed for each patient. For the patients who agreed on additional examination for their children, children’s growth, medical history and antibody to hepatitis B surface antigen (anti-HBs) titer were checked.

Results:
All 18 patients had been diagnosed with Crohn’s disease. There was not any case of preterm delivery, low birth-weight infant, congenital anomaly, nor stillbirth. All 12 children had followed the regular vaccination schedule for hepatitis B and 4 of them showed negative results for anti-HBs. After the 1 booster vaccination, all children demonstrated seroconversion. Regarding live vaccines, 4 children had bacillus Calmette-Guerin and 4 had rotavirus vaccine before 6 months, without any specific side effects.

Conclusions:
This was the first study of immunity of the children born from IBD women who had been treated with anti-TNF-α medication during their pregnancy. IBD women had comparable pregnancy outcomes with the general women population, suggesting that the disease activity rather than the administered medication would be more important in healthy pregnancy. Considering the history of vaccination and anti-HBs titers, immunity seems to be intact in the children.
Keimyung Author(s)(Kor)
김은수
조광범
Publisher
School of Medicine (의과대학)
Citation
Ko Eun Lee et al. (2019). Influence of anti-tumor necrosis factor-alpha therapy on pregnant women with inflammatory bowel disease and their children’s immunity. Intestinal Research, 17(2), 237–243. doi: 10.5217/ir.2018.00071
Type
Article
ISSN
2288-1956
Source
https://irjournal.org/journal/view.php?doi=10.5217/ir.2018.00071
DOI
10.5217/ir.2018.00071
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41923
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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