계명대학교 의학도서관 Repository

Differential cutoff points and clinical impact of stent parameters of various drug-eluting stents for predicting major adverse clinical events: An individual patient data pooled analysis of seven stent-specific registries and 17,068 patients

Metadata Downloads
Author(s)
Cheol Hyun LeeDo-Yoon KangMinkyu HanSeung-Ho HurSeung-Woon RhaSung-Ho HerKi-Bae SeungKee-Sik KimgPil-Hyung LeeJung-Min AhnSeung-Whan LeeSeong-Wook ParkDuk-Woo ParkSeung-Jung Park
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
International Journal of Cardiology
Issued Date
2019
Volume
282
Keyword
Coronary artery diseaseDrug-eluting stentsPercutaneous coronary intervention
Abstract
Background:
Stent parameters (length and diameter) arewell-known risk factors for adverse outcomes after percutaneous coronary intervention (PCI) with stenting. This study aimed to investigate the differential cutoff criteria and clinical impact of the length and diameter of various drug-eluting stents (DES) for predicting major cardiovascular events.

Methods:
Using patient-level data fromseven stent-specific, prospectiveDES registries,we evaluated 17,068 patients who underwent PCIwith either various contemporary DES or first-generation DES between July 2007 and July 2015: 3053 treated with cobalt-chromium everolimus-eluting stents (CoCr-EES), 2976 with platinum-chromium EES (PtCr-EES), 2888 with Resolute zotarolimus-eluting stents (Re-ZES), 782 with Biomatrix biolimus-eluting stents (Bi-BES), 1868 with Nobori BES (No-BES), 1934 with Xience Prime cobalt-chromium EES (Pr-CoCr-EES), and 3567 with first-generation sirolimus-eluting stents (SES). Two clinical outcomes were assessed: target-vessel failure (TVF; a composite of cardiac death, target-vessel myocardial infarction, and target-vessel revascularization [TVR]) and TVR.

Results:
Stent length and stent diameterwere important factors for predicting TVF or TVR in the entire cohort and in each DES cohort. For TVF risk prediction, the Youden index-based cutoff of stent lengthwas highestwith Bi-BES (45.0 mm) and lowest with No-BES (29.0 mm), and the cutoff of stent diameter was smallest with Pr-CoCr-EES (2.78mm) and largestwith No-BES (3.20mm). For TVR risk prediction, the cutoff of stent lengthwas the highest with PtCr-EES (48.0 mm) and the lowest with No-BES (29.0 mm), and the cutoff of stent diameter was smallest with CoCr-EES (2.72 mm) and largest with first-generation SES (3.30 mm). The 3-year TVF and TVR rates were substantially different according to the presence or absence of long lesions and small vessels determined using these cutoff points.

Conclusions:
For contemporary PCI practice involving diverse types of DES,we identified differential cutoff points of stent length and diameter for predicting adverse clinical outcomes. The clinical impact of these stent parameters on outcomes and its magnitude varied according to different DES.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine (의과대학)
Citation
Cheol Hyun Lee et al. (2019). Differential cutoff points and clinical impact of stent parameters of various drug-eluting stents for predicting major adverse clinical events: An individual patient data pooled analysis of seven stent-specific registries and 17,068 patients. International Journal of Cardiology, 282, 17–23. doi: 10.1016/j.ijcard.2019.01.108
Type
Article
ISSN
1874-1754
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0167527318340828
DOI
10.1016/j.ijcard.2019.01.108
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41929
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.