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Serum Levels of Eosinophil-Derived Neurotoxin: A Biomarker for Asthma Severity in Adult Asthmatics

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Author(s)
Youngsoo LeeJi-Ho LeeEun-Mi YangEunMi KwonChang-Gyu JungSu-Chin KimYoungwoo ChoiYou Sook ChoChang-Keun KimHae-Sim Park
Keimyung Author(s)
Jung, Chang Gyu
Department
Dept. of Internal Medicine (내과학)
Journal Title
Allergy, Asthma & Immunology Research
Issued Date
2019
Volume
11
Issue
3
Keyword
Eosinophil-derived neurotoxinasthmabiomarkers
Abstract
Purpose:
Eosinophilic inflammation is a key component of severe asthma (SA). However, there has been no reliable serum biomarker for the eosinophili inflammation of SA. We hypothesized that serum eosinophil-derived neurotoxin (EDN) could predict the eosinophilic inflammation of SA in adult asthmatics.

Methods:
Severe asthmatics (n = 235), nonsevere asthmatics (n = 898), and healthy controls (n = 125) were enrolled from Ajou University Hospital, South Korea. The serum levels of EDN and periostin were measured by enzyme-linked immunosorbent assay and compared between severe and nonsevere asthmatics. Their associations with total eosinophil count (TEC) and clinical parameters were evaluated; clinical validation of the K-EDN kit for the measurement of serum EDN was evaluated.

Results:
Severe asthmatics were older and had longer disease duration with significantly lower levels of forced expiratory volume in 1 second and methacholine PC20 than nonsevere asthmatics. Significant differences were found in TEC or sputum eosinophil count (%) between the groups. The serum levels of EDN and periostin were significantly higher in severe asthmatics than in nonsevere asthmatics and in healthy controls (all P < 0.05). Although significant correlations were found between serum EDN levels measured by the 2 kits (ρ = 0.545, P < 0.0001), higher correlation coefficients between serum EDN levels measured by the K-EDN kit and TEC were higher (ρ = 0.358, P < 0.0001) than those between serum EDN levels measured by the MBL kit and TEC (ρ = 0.319, P < 0.0001) or serum periostin level (ρ = 0.222, P < 0.0001). Multivariate regression analysis demonstrated that serum EDN levels measured by the K-EDN kit predicted the phenotype of SA (P = 0.003), while 2 other biomarkers did not.

Conclusions:
The serum EDN level may be a useful biomarker for assessing asthma severity in adult asthmatics.
Keimyung Author(s)(Kor)
정창규
Publisher
School of Medicine (의과대학)
Citation
Youngsoo Lee et al. (2019). Serum Levels of Eosinophil-Derived Neurotoxin: A Biomarker for Asthma Severity in Adult Asthmatics. Allergy, Asthma & Immunology Research, 11(3), 394–405. doi: 10.4168/aair.2019.11.3.394
Type
Article
ISSN
2092-7363
Source
https://e-aair.org/DOIx.php?id=10.4168/aair.2019.11.3.394
DOI
10.4168/aair.2019.11.3.394
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41967
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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