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Low-Normal Free Thyroxine Levels in Euthyroid Male Are Associated with Prediabetes

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Author(s)
Sung Woo KimJae-Han JeonJun Sung MoonEon Ju JeonMi-Kyung KimIn-Kyu LeeJung Beom SeoKeun-Gyu Park
Keimyung Author(s)
Kim, Mi Kyung
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diabetes Metab J
Issued Date
2019
Volume
43
Issue
5
Keyword
Blood glucoseGlycated hemoglobin APrediabetic stateThyroxine
Abstract
Abnormal thyroid function is associated with impaired glucose homeostasis. This study aimed to determine whether free thyroxine (FT4) influences the prevalence of prediabetes in euthyroid subjects using a cross-sectional survey derived from the Korea National Health and Nutrition Examination Survey, conducted between 2013 and 2015. We studied 2,399 male participants of >20 years of age who were euthyroid and non-diabetic. Prediabetic participants had lower FT4 concentrations than those without prediabetes, but their thyrotropin concentrations were similar. We stratified the population into tertiles according to FT4 concentration. After adjusting for multiple confounding factors, glycosylated hemoglobin (HbA1c) levels significantly decreased with increasing FT4 tertile, whereas fasting plasma glucose (FPG) levels were not associated with FT4 tertiles (HbA1c, P<0.01 in T3 vs. T1; FPG, P=0.489 in T3 vs. T1). The prevalence of prediabetes was significantly higher in T1 (odds ratio, 1.426; 95% confidence interval, 1.126 to 1.806; P<0.01) than in T3. In conclusion, subjects with low-normal serum FT4 had high HbA1c and were more likely to have prediabetes. These results suggest that low FT4 concentration is a risk factor for prediabetes in male, even when thyroid function is within the normal range.
Keimyung Author(s)(Kor)
김미경
Publisher
School of Medicine (의과대학)
Citation
Sung Woo Kim et al. (2019). Low-Normal Free Thyroxine Levels in Euthyroid Male Are Associated with Prediabetes. Diabetes Metab J, 43(5), 718–726. doi: 10.4093/dmj.2018.0222
Type
Article
ISSN
2233-6087
Source
https://e-dmj.org/DOIx.php?id=10.4093/dmj.2018.0222
DOI
10.4093/dmj.2018.0222
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41980
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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