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Amoebic Encepha l itis Caused by Balamuthia mandrillaris

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Author(s)
Su Jung KumHye Won LeeHye Ra JungMisun ChoeSang Pyo Kim
Keimyung Author(s)
Lee, Hye WonJung, Hye RaChoe, Mi SunKim, Sang Pyo
Department
Dept. of Pathology (병리학)
Journal Title
Journal of Pathology and Translational Medicine
Issued Date
2019
Volume
53
Issue
5
Keyword
Amoebic encephalitisBalamuthia mandrillarisHistopathologic features
Abstract
We present the case of a 71 year old male who was diagnosed with amoebic encephalitis caused by Balamuthia mandrillaris . He had rheumatic arthritis for 30 years and had undergone continuous tr eatment with immunosuppressants. First, he complained of partial spasm from the left thigh to the left upper limb. Magnetic resonance imaging revealed multifocal enhancing nodules in the cortical and subcortical area of both cerebral hemispheres, which wer e suggestive of brain metastases. However, the patient developed fever with stuporous mentality and an open biopsy was performed immediately. Microscopically, numerous amoebic trophozoites measuring 20 to 25 m in size, with nuclei containing one to four nucleoli and some scattered cysts having a double  layered wall were noted in the background of hemorrhagic necrosis. Based on the microscopic findings , amoebic encephalitis caused by Balamuthia mandrillaris was diagnosed. The patient died on the 10th day after being admitted at the hospital . The diagnosis of amoebic encephalitis in the early stage is difficult for clinicians. Moreover, most cases undergo rapid deterioration, resulting in fatal consequences. In th is report, we present the first case of Balamuthia mandrillaris amoebic encephalitis with fatal progression in a Korean patient.
Keimyung Author(s)(Kor)
이혜원
정혜라
최미선
김상표
Publisher
School of Medicine (의과대학)
Citation
Su Jung Kum et al. (2019). Amoebic Encepha l itis Caused by Balamuthia mandrillaris. Journal of Pathology and Translational Medicine, 53(5), 327–331. doi: 10.4132/jptm.2019.05.14
Type
Article
ISSN
2383-7845
Source
https://www.jpatholtm.org/journal/view.php?doi=10.4132/jptm.2019.05.14
DOI
10.4132/jptm.2019.05.14
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42015
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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