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A phase II trial of bendamustine, carboplatin, and dexamethasone for refractory or relapsed peripheral T-cell lymphoma (BENCART trial)

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Author(s)
Byeong-Bae ParkWon Seog KimCheolwon SuhJung Yong HongDeok-Hwan YangWon Sik LeeYoung Rok DoJong-Ho WonMin Kyoung KimJae-Cheol JoShin Young HyunJeong-A KimYoung Ha OhSeung-Sook LeeYoung Il Koh
Keimyung Author(s)
Do, Young Rok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Leukemia & Lymphoma
Issued Date
2019
Keyword
Lymphoma and Hodgkin diseaseneoplasiasalvage therapybendamustine
Abstract
This trial was designed to investigate the efficacy and toxicity of bendamustine, carboplatin, and dexamethasone (BCD) for relapsed or refractory peripheral T-cell lymphomas (PTCLs), which would be expected to exhibit more promising clinical outcomes compared with bendamustine therapy alone. After treatments with BCD, eight patients exhibited a complete response (CR; 29%) and seven exhibited a partial response (PR; 25%). The overall response rate (ORR) was 54%. Five patients proceeded to ASCT and three patients finally achieved CR. The median progression-free survival (PFS) was 4.4 months (2.8–6.0, 95% CI). For a total of 85 cycles of BCD, grade 3 or 4 neutropenia, thrombocytopenia, and anemia occurred in 17.6, 38.8, and 16.5% of cycles, respectively. Only one patient experienced febrile neutropenia. BCD was a considerable salvage regimen for relapsed or refractory PTCLs with acceptable toxicity; AITL or ASCT eligible patients were more effective to BCD.
Keimyung Author(s)(Kor)
도영록
Publisher
School of Medicine (의과대학)
Citation
Byeong-Bae Park et al. (2019). A phase II trial of bendamustine, carboplatin, and dexamethasone for refractory or relapsed peripheral T-cell lymphoma (BENCART trial). Leukemia & Lymphoma. doi: 10.1080/10428194.2019.1622100
Type
Article
ISSN
1029-2403
Source
https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1622100
DOI
10.1080/10428194.2019.1622100
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42027
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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