계명대학교 의학도서관 Repository

Association between primary immunodeficiency and asthma exacerbation in adult asthmatics

Metadata Downloads
Author(s)
So-Hee LeeGa-Young BanSu-Chin KimChang-Gyu ChungHyun-Young LeeJi-Ho LeeHae-Sim Park
Keimyung Author(s)
Jung, Chang Gyu
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Journal of Internal Medicine
Issued Date
2019
Keyword
Immunologic deficiency syndromesPrevalenceAsthma exacerbationImmunoglobulinsAsthma
Abstract
Background/Aims:
Primary immunodef iciency (PID) is a serious comorbid condition in adult asthmatics that have frequent exacerbations, which requires monthly replacement of intravenous immunoglobulin (IVIG). However, the prevalence and clinical significance of PID in adult asthmatics in Korea have not yet been reported. The aim of this study is to assess the prevalence of PID and its association with asthma exacerbation in Korean adult asthmatics.

Methods:
A total of 2,866 adult asthmatics were enrolled in this study. The PID group was defined as subjects who had lower levels of immunoglobulin G (IgG)/A/M and/or IgG subclass presenting with recurrent respiratory infections. Serum samples were assayed for total IgG/A/M by immunoturbidimetry, and IgG subclasses by nephelometry.

Results:
Of the 2,866 asthmatic patients enrolled, 157 (5.49%) had PID (classified as the PID group), while those without PID was classified as the non-PID group. IgG subclass deficiency (58%) is most prevalent, among which IgG3 subclass deficiency was most common (58%). The relative risk of asthma exacerbation was 1.70 times higher in the PID group compared to the non-PID group (1.696; 95% confidence interval, 1.284 to 2.239; p < 0.001); the prevalence of severe asthma was significantly higher in the PID group than in the non-PID group (32.48% vs. 13.00%, p < 0.001). Thirty-five among 157 patients in the PID group d maintained IVIG to prevent asthma exacerbation.

Conclusions:
It is suggested that PID, especially IgG3 subclass deficiency, is a significant risk factor for asthma exacerbation. Screening of IgG subclass levels and IVIG replacement should be considered in the management in adult asthmatics.
Keimyung Author(s)(Kor)
정창규
Publisher
School of Medicine (의과대학)
Citation
So-Hee Lee et al. (2019). Association between primary immunodeficiency and asthma exacerbation in adult asthmatics. Korean Journal of Internal Medicine. doi: 10.3904/kjim.2018.413
Type
Article
ISSN
2005-6648
Source
http://kjim.org/journal/view.php?doi=10.3904/kjim.2018.413
DOI
10.3904/kjim.2018.413
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42031
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.