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Anticoagulation After Stroke in Patients With Atrial Fibrillation : To Bridge or Not With Low-Molecular-Weight Heparin?

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Author(s)
Riccardo AltavillaValeria CasoFabio BandiniGiancarlo AgnelliGeorgios TsivgoulisShadi YaghiKaren L. FuriePrasanna TadiCecilia BecattiniMarialuisa ZeddeAzmil H. Abdul-RahimKennedy R. LeesAndrea AlbertiMichele VentiMonica AcciarresiCataldo D’AmoreMaria Giulia MosconiLudovica Anna CiminiJessica FusaroPaolo BoviMonica CarlettiAlberto RigatelliManuel CappellariJukka PutaalaLiisa TomppoTurgut TatlisumakSimona MarcheselliAlessandro PezziniLoris PoliAlessandro PadovaniLuca MasottiVieri VannucchiSung-Il SohnGianni LorenziniRossana TassiFrancesca GuideriMaurizio AcampaGiuseppe MartiniGeorge NtaiosGeorge AthanasakisKonstantinos MakaritsisEfstathia KaragkioziKonstantinos VadikoliasChrysoula LiantiniotiMaria ChondrogianniNicola MumoliDomenico ConsoliFranco GalatiSimona SaccoAntonio CaroleiCindy TiseoFrancesco CoreaWalter AgenoMarta BellesiniGiorgio SilvestrelliAlfonso CicconeAlessia LanariUmberto ScodittiLicia DentiMichelangelo MancusoMiriam MaccarroneLeonardo UliviGiovanni OrlandiNicola GianniniGino GialdiniTiziana TassinariMaria Luisa De LodoviciGiorgio BonoChristina RueckertAntonio BaldiSebastiano D’AnnaDanilo ToniFederica LetteriMartina GiuntiniEnrico Maria LottiYuriy FlominAlessio PieroniOdysseas KargiotisTheodore KarapanayiotidesSerena MonacoMario Maimone BaronelloLaszló CsibaLilla SzabóAlberto ChitiElisa GiorliMassimo Del SetteDavide ImbertiDorjan ZabzuniBoris DoroninVera VolodinaPatrik MichelPeter VanackerKristian BarlinnLars-Peder PallesenJessica BarlinnDirk DeleuGayane MelikyanFaisal IbrahimNaveed AkhtarVanessa GourbaliMaurizio Paciaroni
Keimyung Author(s)
Sohn, Sung Il
Department
Dept. of Neurology (신경과학)
Journal Title
Stroke
Issued Date
2019
Volume
50
Issue
8
Keyword
anticoagulantsatrial fibrillationhumansincidencesecondary prevention
Abstract
Background and Purpose
—Bridging therapy with low-molecular-weight heparin reportedly leads to a worse outcome for acute cardioembolic stroke patients because of a higher incidence of intracerebral bleeding. However, this practice is common in clinical settings. This observational study aimed to compare (1) the clinical profiles of patients receiving and not receiving bridging therapy, (2) overall group outcomes, and (3) outcomes according to the type of anticoagulant prescribed.

Methods
—We analyzed data of patients from the prospective RAF and RAF-NOACs studies. The primary outcome was defined as the composite of ischemic stroke, transient ischemic attack, systemic embolism, symptomatic cerebral bleeding, and major extracerebral bleeding observed at 90 days after the acute stroke.

Results
—Of 1810 patients who initiated oral anticoagulant therapy, 371 (20%) underwent bridging therapy with full-dose low-molecular-weight heparin. Older age and the presence of leukoaraiosis were inversely correlated with the use of bridging therapy. Forty-two bridged patients (11.3%) reached the combined outcome versus 72 (5.0%) of the nonbridged patients (P=0.0001). At multivariable analysis, bridging therapy was associated with the composite end point (odds ratio, 2.3; 95% CI, 1.4–3.7; P<0.0001), as well as ischemic (odds ratio, 2.2; 95% CI, 1.3–3.9; P=0.005) and hemorrhagic (odds ratio, 2.4; 95% CI, 1.2–4.9; P=0.01) end points separately.

Conclusions
—Our findings suggest that patients receiving low-molecular-weight heparin have a higher risk of early ischemic recurrence and hemorrhagic transformation compared with nonbridged patients.
Keimyung Author(s)(Kor)
손성일
Publisher
School of Medicine (의과대학)
Citation
Riccardo Altavilla et al. (2019). Anticoagulation After Stroke in Patients With Atrial Fibrillation : To Bridge or Not With Low-Molecular-Weight Heparin? Stroke, 50(8), 2093–2100. doi: 10.1161/STROKEAHA.118.022856
Type
Article
ISSN
1524-4628
Source
https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.118.022856
DOI
10.1161/STROKEAHA.118.022856
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42038
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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