계명대학교 의학도서관 Repository

Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer

Metadata Downloads
Author(s)
Jin Won KimJong Gwang KimByung Woog KangIk-Joo ChungYoung Seon HongTae-You KimHong Suk SongKyung Hee LeeDae Young ZangYoon Ho KoEun-Kee SongJin Ho BaekDongHoe KooSo Yeon OhHana ChoKeun-Wook Lee
Keimyung Author(s)
Song, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancer Research and Treatment
Issued Date
2019
Volume
51
Issue
1
Keyword
Advanced gastric cancerFirst-line palliative chemotherapyQuality of life
Abstract
Purpose:
The purpose of this study was to evaluate chemotherapy patterns and changes in quality of life (QOL) during first-line palliative chemotherapy for Korean patients with unresectable or metastatic/recurrent gastric cancer (GC).

Materials and Methods:
Thiswas a non-interventional, multi-center, prospective, observational study of 527 patients in Korea. QOL assessments were conducted using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ)-C30 and QLQ-STO22 every 3 months over a 12-month period during first-line palliative chemotherapy. The specific chemotherapy regimens were selected by individual clinicians.

Results:
Most patients (93.2%) received combination chemotherapy (mainly fluoropyrimidine plus platinum) as their first-line palliative chemotherapy. The median progression-free survival and overall survival were 8.2 and 14.8 months, respectively. Overall, “a little” changes (differences of 5-10 points from baseline)were observed in some of the functioning or symptom scales; none of the QOL scales showed either “moderate” or “very much” change (i.e., ≥ 11 point difference from baseline). When examining the best change in each QOL domain from baseline, scales related to some aspects of functioning, global health status/QOL, and most symptoms revealed significant improvements (p < 0.05). Throughout the course of first-line palliative chemotherapy, most patients’ QOL was maintained to a similar degree, regardless of their actual response to chemotherapy.

Conclusion:
This observational study provides important information on the chemotherapy patterns and QOL changes in Korean patientswith advanced GC. Overall, first-line palliative chemotherapy was found to maintain QOL, and most parameters showed an improvement compared with the baseline at some point during the course.
Keimyung Author(s)(Kor)
송홍석
Publisher
School of Medicine (의과대학)
Citation
Jin Won Kim et al. (2019). Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer. Cancer Research and Treatment, 51(1), 223–239. doi: 10.4143/crt.2018.073
Type
Article
ISSN
2005-9256
Source
https://www.e-crt.org/journal/view.php?number=2931
DOI
10.4143/crt.2018.073
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42124
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.