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Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit

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Author(s)
Se Jin KimGa Eun KimJae Hyun ParkSang Lak LeeChun Soo Kim
Keimyung Author(s)
Kim, Se JinKim, Ga EunPark, Jae HyunLee, Sang LakKim, Chun Soo
Department
Dept. of Pediatrics (소아청소년학)
Dept. of Nursing (간호학)
Journal Title
Korean Journal of Pediatrics
Issued Date
2019
Volume
62
Issue
1
Keyword
Early-onset sepsisClinical featuresPrognosisNeonatal intensive care unit
Abstract
Purpose:
In this study, we investigated the clinical features and prognostic factors of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients.

Methods:
A retrospective analysis was conducted on medical records from January 2010 to June 2017 (7.5 years) of a university hospital NICU.

Results:
There were 45 cases of EOS (1.2%) in 3,862 infants. The most common pathogen responsible for EOS was group B Streptococcus (GBS), implicated in 10 cases (22.2%), followed by Escherichia coli, implicated in 9 cases (20%). The frequency of gram-positive sepsis was higher in term than in preterm infants, whereas the rate of gram-negative infection was higher in preterm than in term infants (P<0.05). The overall mortality was 37.8% (17 of 45), and 47% of deaths occurred within the first 3 days of infection. There were significant differences in terms of gestational age (26.8 weeks vs. 35.1 weeks) and birth weight (957 g vs. 2,520 g) between the death and survival groups. After adjustments based on the difference in gestational age and birth weight between the 2 groups, gram-negative pathogens (odds ratio [OR], 42; 95% confidence interval [CI], 1.4–1,281.8) and some clinical findings, such as neutropenia (OR, 46; 95% CI, 1.3–1,628.7) and decreased activity (OR, 34; 95% CI, 1.8–633.4), were found to be associated with fatality.

Conclusion:
The common pathogens found to be responsible for EOS in NICU patients are GBS and E. coli. Gram-negative bacterial infections, decreased activity in the early phase of infection, and neutropenia were associated with poor outcomes.
Keimyung Author(s)(Kor)
김세진
김가은
박재현
이상락
김천수
Publisher
School of Medicine (의과대학)
College of Nursing (간호대학)
Citation
Se Jin Kim et al. (2019). Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit. Korean Journal of Pediatrics, 62(1), 36–41. doi: 10.3345/kjp.2018.06807
Type
Article
ISSN
2092-7258
Source
https://www.kjp.or.kr/journal/view.php?number=20125553479
DOI
10.3345/kjp.2018.06807
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42128
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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