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Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress

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Author(s)
Youra KangJi-Ha LeeYoung Ho SeoJung-Hee JangChul-Ho JeongSooyeun LeeGil-Saeng JeongByoungduck Park
Keimyung Author(s)
Jang, Jung Hee
Department
Dept. of Pharmacology (약리학)
Journal Title
Biomolecules & Therapeutics
Issued Date
2019
Volume
27
Issue
2
Keyword
EpicatechinMethamphetamineNeuroprotection
Abstract
Methamphetamine (METH) acts strongly on the nervous system and damages neurons and is known to cause neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Flavonoids, polyphenolic compounds present in green tea, red wine and several fruits exhibit antioxidant properties that protect neurons from oxidative damage and promote neuronal survival. Especially, epicatechin (EC) is a powerful flavonoid with antibacterial, antiviral, antitumor and antimutagenic effects as well as antioxidant effects. We therefore investigated whether EC could prevent METH-induced neurotoxicity using HT22 hippocampal neuronal cells. EC reduced METH-induced cell death of HT22 cells. In addition, we observed that EC abrogated the activation of ERK, p38 and inhibited the expression of CHOP and DR4. EC also reduced METH-induced ROS accumulation and MMP. These results suggest that EC may protect HT22 hippocampal neurons against METH-induced cell death by reducing ER stress and mitochondrial damage.
Keimyung Author(s)(Kor)
장정희
Publisher
School of Medicine (의과대학)
Citation
Youra Kang et al. (2019). Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress. Biomolecules & Therapeutics, 27(2), 145–151. doi: 10.4062/biomolther.2018.092
Type
Article
ISSN
2005-4483
Source
http://www.biomolther.org/journal/view.html?uid=1066&vmd=Full
DOI
10.4062/biomolther.2018.092
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42148
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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