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Multicenter Planning Comparison of Stereotactic Body Radiotherapy for Hepatocellular Carcinoma with Major Portal Vein Tumor Thrombosis (KROG 16-17)

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Author(s)
Sun Hyun BaeMi-Sook KimWon Il JangJin Ho KimWoo Chul KimJin hee KimBae-Kwon JeongYong Ho KimSunmi JoChul Won ChoiYounghee ParkKwang Hwan Cho
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Journal of Liver Cancer
Issued Date
2018
Volume
18
Issue
2
Keyword
Hepatocellular carcinomaMulticenter studyPortal veinStereotactic body radiotherapySurvey
Abstract
Background/Aims:
To evaluate the technical feasibility of stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) with the major portal vein tumor thrombosis (PVTT).

Methods:
Ten institutions affiliated with the Korean Stereotactic Radiosurgery Group were provided the contours of four cases: the first case was the first branch PVTT with sufficient normal liver volume (NLV), the second was the first branch PVTT with insufficient NLV, the third was the main trunk PVTT at confluence level, and the fourth was the main trunk PVTT with entire length. The institutions were asked to make SBRT plans according to their current treatment protocols and to complete facility questionnaires.

Results:
Based on institutional protocols, SBRT was feasible in nine institutions for the first case (32-60 Gy in 3-5 fractions), in eight institutions for the second case (32-50 Gy in 3-5 fractions), in seven institutions for the third case (35-60 Gy in 3-5 fractions), and in four institutions for the fourth case (35-42 Gy in 4-5 fractions). The other institutions recommended hypo- or conventional fractionation due to insufficient NLV or gastrointestinal organ proximity. With analysis of the SBRT dose to the central hepatobiliary tract, the major PVTT could theoretically be associated with a high risk of hepatobiliary toxicity.

Conclusions:
Although SBRT is a technically feasible option for HCC with the major PVTT, there was a variability among the participating institutions. Therefore, further studies will be necessary to standardize the practice of SBRT for the major PVTT.
Alternative Title
주요간문맥종양혈전을 동반한 간세포암에 대한 다기관 체부정위방사선치료계획 비교연구(KROG 16-17)
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine (의과대학)
Citation
Sun Hyun Bae et al. (2018). Multicenter Planning Comparison of Stereotactic Body Radiotherapy for Hepatocellular Carcinoma with Major Portal Vein Tumor Thrombosis (KROG 16-17). Journal of Liver Cancer, 18(2), 130–141. doi: 10.17998/jlc.18.2.130
Type
Article
ISSN
2383-5001
Source
https://www.e-jlc.org/journal/view.php?number=407
DOI
10.17998/jlc.18.2.130
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42225
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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