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New Oral Anticoagulants를 복용하는 환자들에서 위장관 출혈의 위험인자

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Author(s)
Ju Yup Lee
Keimyung Author(s)
Lee, Ju Yup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Journal of Helicobacter and Upper Gastrointestinal Research
Issued Date
2018
Volume
18
Issue
4
Keyword
ApixabanDabigatranEdoxabanGastrointestinal hemorrhageRivaroxaban
Abstract
New oral anticoagulants (NOACs) are now widely used for the prevention and treatment of venous thrombosis, and for the prevention of stroke and systemic embolism in patients with atrial fibrillation. As compared with warfarin, NOACs have the advantage of rapid onset of action and less drug interaction. However, they carry a higher risk of gastrointestinal (GI) bleeding than warfarin. The risk of GI bleeding in patients using NOACs varies according to the type and dose of the drug. By contrast, apixaban and edoxaban are reported to carry similar risks as warfarin, and the risks with dabigatran and rivaroxaban are higher than that with warfarin. In patients using NOACs, old age, impaired renal function, impaired liver function, concurrent use of antiplatelet agents, and nonsteroidal anti-inflammatory drugs are considered major risk factors of GI bleeding, and gastroprotective agents such as histamine-2 receptor antagonist and proton pump inhibitor have preventive effects. To prevent GI bleeding associated with NOACs, the characteristics of each NOAC and the risk factors of bleeding should be recognized.
Alternative Title
Risk Factors of Gastrointestinal Bleeding in Patients Receiving New Oral Anticoagulants
Keimyung Author(s)(Kor)
이주엽
Publisher
School of Medicine (의과대학)
Citation
Ju Yup Lee. (2018). New Oral Anticoagulants를 복용하는 환자들에서 위장관 출혈의 위험인자. Korean Journal of Helicobacter and Upper Gastrointestinal Research, 18(4), 219–224. doi: 10.7704/kjhugr.2018.18.4.219
Type
Article
ISSN
1738-3331
Source
https://www.helicojournal.org/journal/view.php?number=11
DOI
10.7704/kjhugr.2018.18.4.219
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42243
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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