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Synchronous Bilateral Breast Carcinoma in a Patient with Cowden Syndrome with PTEN Mutation: A Case Report

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Author(s)
Sun Young KwonSoo Hyun YeoJung Sook HaSun Hee Kang
Keimyung Author(s)
Kwon, Sun YoungYeo, Soo HyunHa, Jung SookKang, Sun Hee
Department
Dept. of Pathology (병리학)
Dept. of Radiology (영상의학)
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Surgery (외과학)
Journal Title
Journal of Breast Disease
Issued Date
2018
Volume
6
Issue
2
Keyword
Breast neoplasmsCowden syndromeMutationPTEN gene
Abstract
Cowden syndrome (CS), also known as multiple hamartomas syndrome, is a rare hereditary autosomal dominant disorder caused by a germline mutation in the phosphatase and tensin homolog (PTEN) gene mapped on chromosome 10. The clinical features of CS are variable, primarily presenting as mucocutaneous lesions (99%). A mucocutaneous lesion, such as trichilemmoma of the face or keratosis of the extremities, is an important diagnostic marker for CS. CS has been reported to increase the incidence of benign and malignant neoplasms in the breast, thyroid, and gastrointestinal tract. The risk of developing malignancy in individuals with CS is up to 10 times higher than general population throughout an entire life time.
Keimyung Author(s)(Kor)
권선영
여수현
하정숙
강선희
Publisher
School of Medicine (의과대학)
Citation
Sun Young Kwon et al. (2018). Synchronous Bilateral Breast Carcinoma in a Patient with Cowden Syndrome with PTEN Mutation: A Case Report. Journal of Breast Disease, 6(2), 79–83. doi: /10.14449/jbd.2018.6.2.79
Type
Article
ISSN
2288-5560
Source
https://www.jbd.or.kr/journal/view.php?doi=10.14449/jbd.2018.6.2.79
DOI
/10.14449/jbd.2018.6.2.79
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42247
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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