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A study of the effectiveness of using the serum procalcitonin level as a predictive test for bacteremia in acute pyelonephritis

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Author(s)
Ga Hee LeeYoo Jin LeeYang Wook KimSihyung ParkJinhan ParkKang Min ParkKyubok JinBong Soo Park
Keimyung Author(s)
Jin, Kyu Bok
Department
Dept. of Internal Medicine (내과학)
Journal Title
고신대학교 의과대학 학술지
Issued Date
2018
Volume
33
Issue
3
Keyword
BacteremiaProcalcitoninPyelonephritis
Abstract
Objectives:
Serum procalcitonin (PCT) is a specific biomarker that rises after bacterial infection, and levels of PCT are known to correlate with the severity and mortality of patients with pneumonia and sepsis. However, the usefulness of PCT levels in acute pyelonephritis is unknown. This study aimed to evaluate the effectiveness of using the PCT level as a predictive test for bacteremia in acute pyelonephritis.

Methods:
Between January 2012 and June 2013, 140 patients diagnosed with acute pyelonephritis were admitted to Haeundae Paik Hospital. Serum PCT, C-reactive protein (CRP), and white blood cell (WBC) levels at preand post- treatment were measured. Blood and urine cultures were obtained from all patients. The levels of PCT, CRP, and WBCs were each compared between the blood culture-positive and blood culture-negative groups to assess their effectiveness in predicting bacteremia.

Results:
Pre-treatment PCT level was 0.77 ng/mL (95% CI: 0.42–1.60 ng/mL) in the blood culture-negative group and 4.89 ng/mL (95% CI: 2.88–9.04 ng/mL) in the blood culture-positive group, and the increase between the two groups was statistically significant. The area under the receiver operating characteristic curve of PCT level for prediction of bacteremia was 0.728. A cut-off value of 1.23 ng/mL indicated a sensitivity of 79.0 % and specificity of 60.0 % for PCT level.

Conclusions:
Serum PCT level is a useful predictive test for bacteremia in acute pyelonephritis. Through the early detection of bacteremia, serum PCT level can help estimate the prognosis and predict complications such as sepsis.
Keimyung Author(s)(Kor)
진규복
Publisher
School of Medicine (의과대학)
Citation
Ga Hee Lee et al. (2018). A study of the effectiveness of using the serum procalcitonin level as a predictive test for bacteremia in acute pyelonephritis. 고신대학교 의과대학 학술지, 33(3), 337–346. doi: 10.7180/kmj.2018.33.3.337
Type
Article
ISSN
2586-7024
Source
http://kmj.kucm.ac.kr/journal/view.html?multi%5B%5D=1777&tops=&book=Journal&start=0&scale=50&authkey=&keykey=&key_1=&titlekey=&tit_1=&abskey=&abs_1=&Vol=033&Num=03&PG=&year1=&year2=&sort=Regnum-0&aut_box=Y&sub_box=Y&sos_box=&key_box=&pub_box=Y&abs_box=&mod=vol&sflag=&language=&uid=&year=2018
DOI
10.7180/kmj.2018.33.3.337
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42264
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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