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Outcome of Breast-Conserving Treatment for Axillary Lymph Node Metastasis From Occult Breast Cancer With Negative Breast MRI

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Author(s)
Haeyoung KimWon ParkSu Ssan KimSung Ja AhnYong Bae KimTae Hyun KimJin Hee KimJin-Hwa ChoiHae Jin ParkJee Suk Chang Doo Ho Choi a
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Breast
Issued Date
2019
Volume
49
Keyword
NeoplasmsUnknown primaryBreast neoplasmLymph nodesMagnetic resonance imagingRadiotherapy
Abstract
Purpose:
We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC).

Materials and methods:
Survival rates and failure patterns in 66 patients who received axillary lymph node dissection (ALND) and BCT for MRI-OBC between 2001 and 2013 at seven hospitals were analyzed. OBC was defined as adenocarcinoma in the axillary lymph node (ALN) +/- supraclavicular (SCN) or internal mammary lymph node (IMN) with a negative breast MRI.

Results:
Fifty-four patients had only ALN metastasis (ALN only), and 12 patients had ALN metastasis along with SCN or IMN metastasis (ALN + SCN/IMN). Median follow-up was 82 months. The 5-year overall, disease-free, and breast cancer-free survival rates were 93.4%, 92.1%, and 96.8%, respectively. Nine patients experienced recurrence: breast (n = 4), regional lymph nodes (RLN, n = 1), distant metastases (DM, n = 2), breast/RLN (n = 1), and breast/RLN/DM (n = 1). Five-year disease-free survival was significantly higher in ALN only patients compared to ALN + SCN/IMN patients (96.1% vs. 75.0%; p = 0.02).

Conclusions:
Patients with MRI-OBC were successfully treated with BCT. There was a small risk of ipsilateral breast cancer recurrence. Failure patterns depended on the extent of initial disease.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine (의과대학)
Citation
Haeyoung Kim et al. (2019). Outcome of Breast-Conserving Treatment for Axillary Lymph Node Metastasis From Occult Breast Cancer With Negative Breast MRI. Breast, 49, 63–69. doi: 10.1016/j.breast.2019.10.017
Type
Article
ISSN
1532-3080
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0960977619305910
DOI
10.1016/j.breast.2019.10.017
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42321
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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