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The Prognostic Value of PET/CT Evaluation With Deauville Score on the Recurrence and Survival in Diffuse Large B-cell Lymphoma: A Multi-Institutional Study of KROG 17-02

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Author(s)
Jeong Won LeeDongryul OhKeun‑Yong EomJin Hee KimWoo Chul KimMi Joo ChungJong Hoon Lee
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Clinical & experimental metastasis
Issued Date
2019
Keyword
Deauville scoreDiffuse large B-cell lymphomaPrognosisSurvival
Abstract
The Korean Radiation Oncology Group (KROG) assessed the value of Deauville score (DS) on 18F-fluorodeoxyglucose Positron emission tomography-computed tomography (FDG PET/CT) as a predictor of recurrence and survival after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy in diffuse large B-cell lymphoma (DLBCL). A total of 512 patients with stage I–III DLBCL who received six cycles of R-CHOP with or without radiation therapy (RT) and obtained treatment responses according to PET-CT imagings after R-CHOP ± RT were included. Patients were sorted into two arms; DS 4–5 arm (n = 24) was matched at a 1:2 ratio with DS 1–3 arm (n = 48) using propensity score matching method. After a median follow-up time of 37.2 months, the recurrence-free survival rate (86.6% vs. 66.8%, P = 0.041) and overall survival rate (86.9% vs. 62.2%, P = 0.009) at 5 years were significantly different between the DS 1–3 and DS 4–5 arms. DS 4–5 arm showed higher 5-years locoregional recurrence-free survival (88.8% vs. 74.3%, P = 0.155) and distant failure-free survival (91.1% vs. 84.3%, P = 0.333) than DS 1–3 arm. In the multivariate analysis, DS was still a significant factor for recurrence-free survival [hazard ratio (HR), 3.840 and confidence interval (CI), 1.068–13.806; P = 0.039] and overall survival rates (HR 4.453 and CI 1.274–15.562; P = 0.019). This study showed and validated that Deauville score of 4–5 of PET-CT imaging taken after full-course of R-CHOP chemotherapy with or without RT could predict recurrence-free survival and overall survival in DLBCL patients.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine (의과대학)
Citation
Jeong Won Lee et al. (2019). The Prognostic Value of PET/CT Evaluation With Deauville Score on the Recurrence and Survival in Diffuse Large B-cell Lymphoma: A Multi-Institutional Study of KROG 17-02. Clinical & experimental metastasis. doi: 10.1007/s10585-019-09992-z
Type
Article
ISSN
1573-7276
Source
https://link.springer.com/article/10.1007%2Fs10585-019-09992-z
DOI
10.1007/s10585-019-09992-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42335
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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