계명대학교 의학도서관 Repository

Ten-day Concomitant, 10-day Sequential, and 7-day Triple Therapy in First-Line Treatment of Helicobacter pylori Infection: A Randomized Nationwide Trial in Korea

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Author(s)
Beom Jin KimHyuk LeeYong Chan LeeSeong Woo JeonGwang Ha KimHyun-Soo KimJae Kyu SungDong Ho LeeHeung Up KimMoo In ParkIl Ju ChoiSoon Man YoonSang Wook KimGwang Ho BaikJu Yup LeeJin Il KimSang Gyun KimJayoun KimJoongyup LeeJae Gyu Kimand Jae J. Kim
Keimyung Author(s)
Lee, Ju Yup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Gut and Liver
Issued Date
2019
Volume
13
Issue
5
Keyword
Concomitant therapyDisease eradicationHelicobacter pyloriTriple therapySequential therapy
Abstract
Background/Aims:
This nationwide, multicenter prospective randomized controlled trial aimed to compare the efficacy and safety of 10-day concomitant therapy (CT) and 10-day sequential therapy (ST) with 7-day clarithromycin-containing triple therapy (TT) as first-line treatment for Helicobacter pylori infection in the Korean population.

Methods:
Patients with H. pylori infection were assigned randomly to 7d-TT (lansoprazole 30 mg, amoxicillin 1 g, and clarithromycin 500 mg twice daily for 7 days), 10d-ST (lansoprazole 30 mg and amoxicillin 1 g twice daily for the first 5 days, followed by lansoprazole 30 mg, clarithromycin 500 mg, and metronidazole 500 mg twice daily for the remaining 5 days), or 10d-CT (lansoprazole 30 mg, amoxicillin 1 g, clarithromycin 500 mg, and metronidazole 500 mg twice daily for 10 days). The primary endpoint was eradication rate by intention-to-treat (ITT) and per-protocol (PP) analyses.

Results:
A total of 1,141 patients were included. The 10d-CT protocol achieved a markedly higher eradication rate than the 7d-TT protocol in both the ITT (81.2% vs 63.9%) and PP analyses (90.6% vs 71.4%). The eradication rate of the 10d-ST protocol was superior to that of the 7d-TT protocol (76.3% vs 63.9%, ITT analysis; 85.0% vs 71.4%, PP analysis). No significant differences in adherence or serious side effects were found among the three treatment arms.

Conclusions:
The 10d-CT and 10d-ST regimens were superior to the 7d-TT regimen as standard first-line treatment in Korea.
Keimyung Author(s)(Kor)
이주엽
Publisher
School of Medicine (의과대학)
Citation
Beom Jin Kim et al. (2019). Ten-day Concomitant, 10-day Sequential, and 7-day Triple Therapy in First-Line Treatment of Helicobacter pylori Infection: A Randomized Nationwide Trial in Korea. Gut and Liver, 13(5), 531–540. doi: 10.5009/gnl19136
Type
Article
ISSN
2005-1212
Source
http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl19136
DOI
10.5009/gnl19136
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42346
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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