계명대학교 의학도서관 Repository

Primary and Secondary Antibiotic Resistance of Helicobacter Pylori in Korea From 2003 to 2018

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Author(s)
Ju Yup LeeNayoung KimRyoung Hee NamSoo In ChoiJung Won LeeDong Ho Lee
Keimyung Author(s)
Lee, Ju Yup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Helicobacter
Issued Date
2019
Volume
24
Issue
6
Keyword
antibioticsHelicobacter pyloriprevalenceresistance
Abstract
Background:
Antimicrobial resistance of Helicobacter pylori (H pylori) affects the efficacy of eradication therapy. The aim of this study was to estimate the prevalence of primary and secondary resistance of H pylori isolates to antibiotics in Korea.

Methods:
The present study was performed from 2003 to 2018. Primary resistance was evaluated in 591 patients without any history of eradication and secondary resistance in 149 patients from whom Helicobacter pylori was cultured after failure of eradication. A minimal inhibitory concentration test was performed for amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin, and rifabutin using the agar dilution method.

Results:
An increase in the primary resistance rate was found in clarithromycin (P < .001), metronidazole (P < .001), and both levofloxacin (P < .001) during the study period. The primary resistance rates of amoxicillin and tetracycline were low and stable during the study period. The secondary resistance rate significantly increased in metronidazole and levofloxacin (P = .022 and .039, respectively).

Conclusions:
The primary and secondary resistance rates of clarithromycin, metronidazole, and levofloxacin for Helicobacter pylori in Korea were high and increased over time. However, the primary and secondary resistance rates of amoxicillin and tetracycline were low and stable over time. These results will help in selecting effective eradication regimens of H pylori in Korea in the future.
Keimyung Author(s)(Kor)
이주엽
Publisher
School of Medicine (의과대학)
Citation
Ju Yup Lee et al. (2019). Primary and Secondary Antibiotic Resistance of Helicobacter Pylori in Korea From 2003 to 2018. Helicobacter, 24(6), e12660–e12660. doi: 10.1111/hel.12660
Type
Article
ISSN
1523-5378
Source
https://onlinelibrary.wiley.com/doi/full/10.1111/hel.12660
DOI
10.1111/hel.12660
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42348
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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