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Association of Nutritional Status With Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease

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Author(s)
Jae-Won JangYeshin KimYong-Ho ChoiJong-Min LeeBora YoonKyung Won ParkSi Eun KimHee Jin KimSoo Jin YoonJee Hyang JeongEun-Joo KimNa Yeon JungJihye HwangJu-Hee KangJin Yong HongSeong Hye Choi
Keimyung Author(s)
Hwang, Ji Hye
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of clinical neurology
Issued Date
2019
Volume
15
Issue
3
Keyword
nutritional statusdementiacerebral cortex
Abstract
Background and Purpose:
Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential confounders affecting the nutritional status. The purpose of the current study was to determine the nutritional status of participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE) and to identify clinical risk factors for being at risk of malnutrition or being malnourished.

Methods:
Baseline data from 212 participants [119 cognitively unimpaired (CU), 56 with mild cognitive impairment (MCI), and 37 with dementia] included in the KBASE database were analyzed. All participants underwent a comprehensive cognitive test and MRI at baseline. The presence of malnutrition at baseline was measured by the Mini Nutritional Assessment score. We examined the cross-sectional relationships of clinical findings with nutritional status using multiple logistic regression applied to variables for which p<0.2 in the univariate analysis. Differences in cortical thickness according to the nutritional status were also investigated.

Results:
After adjustment for demographic, nutritional, and neuropsychological factors, participants with dementia had a significantly higher odds ratio (OR) for being at risk of malnutrition or being malnourished than CU participants [OR=5.98, 95% CI=1.20–32.97] whereas participants with MCI did not (OR=0.62, 95% CI=0.20–1.83). Cortical thinning in the at-risk/malnutrition group was observed in the left temporal area.

Conclusions:
Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status.
Keimyung Author(s)(Kor)
황지혜
Publisher
School of Medicine (의과대학)
Citation
Jae-Won Jang et al. (2019). Association of Nutritional Status With Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease. Journal of clinical neurology, 15(3), 292–300. doi: 10.3988/jcn.2019.15.3.292
Type
Article
ISSN
2005-5013
Source
https://thejcn.com/DOIx.php?id=10.3988/jcn.2019.15.3.292
DOI
10.3988/jcn.2019.15.3.292
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42358
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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