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Association of Muscle Mass With Survival After Radical Prostatectomy in Patients With Prostate Cancer

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Author(s)
Sahyun PakSeo Young ParkTeak Jun ShinDalsan YouIn Gab JeongJun Hyuk HongChoung-Soo KimHanjong Ahn
Keimyung Author(s)
Shin, Teak Jun
Department
Dept. of Urology (비뇨의학)
Journal Title
Journal of urology
Issued Date
2019
Volume
202
Issue
3
Keyword
prostatic neoplasmssurvival analysisbody compositionprostatectomy
Abstract
Purpose:
Although muscle mass has been associated with survival in patients with various types of solid tumors, the relationship between muscle mass and survival in patients with prostate cancer remains unclear. We retrospectively investigated the association of muscle mass with survival after radical prostatectomy in patients with prostate cancer.

Materials and Methods:
We reviewed the records of 2,042 patients who underwent radical prostatectomy of prostate cancer between 1998 and 2013. Muscle mass was evaluated by measuring the psoas muscle index on preoperative computerized tomography images.

Results:
In the lowest, second, third and highest psoas muscle index quartiles the 10-year distant metastasis-free survival rate was 72.5%, 83.8%, 92.3% and 93.7% (p <0.001), the 10-year cancer specific survival rate was 85.7%, 92.1%, 96.8% and 97.6%, and the 10-year overall survival rate was 74.5%, 79.6%, 89.8% and 90.6%, respectively (each p <0.001). The psoas muscle index positively correlated with the body mass index, serum concentrations of IGFBP-3 and bioavailable testosterone, and inversely correlated with patient age, the serum SHBG concentration and the neutrophil-to-lymphocyte ratio. On multivariable analysis the psoas muscle index was independently associated with increased risks of biochemical recurrence, distant metastasis, and cancer specific and overall death.

Conclusions:
Low muscle mass may be associated with increased risks of recurrence and mortality in patients who undergo radical prostatectomy of prostate cancer regardless of the body mass index. Large-scale prospective studies are warranted.
Keimyung Author(s)(Kor)
신택준
Publisher
School of Medicine (의과대학)
Citation
Sahyun Pak et al. (2019). Association of Muscle Mass With Survival After Radical Prostatectomy in Patients With Prostate Cancer. Journal of urology, 202(3), 525–532. doi: 10.1097/JU.0000000000000249
Type
Article
ISSN
1527-3792
Source
https://www.auajournals.org/doi/10.1097/JU.0000000000000249
DOI
10.1097/JU.0000000000000249
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42376
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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