계명대학교 의학도서관 Repository

Physiologic Characteristics and Clinical Outcomes of Patients With Discordance Between FFR and iFR

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Author(s)
Seung Hun LeeKi Hong ChoiJoo Myung LeeDoyeon HwangTae-Min RheeJonghanne ParkHyun Kuk KimYun-Kyeong ChoHyuck-Jun YoonJinhyoung ParkYoung Bin SongJoo-Yong HahnJoon-Hyung DohChang-Wook NamEun-Seok ShinSeung-Ho HurBon-Kwon Koo
Keimyung Author(s)
Cho, Yun KyeongYoon, Hyuck JunNam, Chang WookHur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
JACC. Cardiovascular interventions
Issued Date
2019
Volume
12
Issue
20
Keyword
coronary artery diseasecoronary flow reservefractional flow reserveinstantaneous wave-free ratioprognosis
Abstract
Objectives:
This study evaluated the physiologic characteristics of discordant lesions between instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR) and the prognosis at 5 years.

Background:
FFR or iFR have been standard methods for assessing the functional significance of coronary artery stenosis. However, limited data exist about the physiologic characteristics of discordant lesions and the prognostic implications resulting from these lesions.

Methods:
A total of 840 vessels from 596 patients were classified according to iFR and FFR; high iFR–high FFR (n = 580), low iFR–high FFR (n = 40), high iFR–low FFR (n = 69), and low iFR–low FFR (n = 128) groups, which were compared with a control group (n = 23). The differences in coronary circulatory indices including the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and resistance reserve ratio (RRR) (resting distal arterial pressure × mean transit time / hyperemic distal arterial pressure × hyperemic mean transit time), which reflect the vasodilatory capacity of coronary microcirculation, were compared. Patient-oriented composite outcomes (POCO) at 5 years including all-cause death, any myocardial infarction, and any revascularization were compared among patients with deferred lesions.

Results:
In the low iFR–high FFR group, CFR, RRR, and IMR measurements were similar to the low iFR–low FFR group: CFR 2.71 versus 2.43 (p = 0.144), RRR 3.36 versus 3.68 (p = 0.241), and IMR 18.51 versus 17.38 (p = 0.476). In the high iFR–low FFR group, the CFR, RRR, and IMR measurements were similar to the control group: CFR 2.95 versus 3.29 (p = 0.160), RRR 4.28 versus 4.00 (p = 0.414), and IMR 17.44 versus 17.06 (p = 0.818). Among the 4 groups, classified by iFR and FFR, CFR and RRR were all significantly different, except for IMR. However, there were no significant differences in the rates of POCO, regardless of discordance between the iFR and FFR. Only the low iFR–low FFR group had a higher POCO rate compared with the high iFR–high FFR group (adjusted hazard ratio: 2.46; 95% confidence interval: 1.17 to 5.16; p = 0.018).

Conclusions:
Differences in coronary circulatory function were found, especially in the vasodilatory capacity between the low iFR–high FFR and high iFR–low FFR groups. FFR–iFR discordance was not related to an increased risk of POCO among patients with deferred lesions at 5 years. (Clinical, Physiological and Prognostic Implication of Microvascular Status; NCT02186093; Physiologic Assessment of Microvascular Function in Heart Transplant Patients; NCT02798731)
Keimyung Author(s)(Kor)
조윤경
윤혁준
남창욱
허승호
Publisher
School of Medicine (의과대학)
Citation
Seung Hun Lee et al. (2019). Physiologic Characteristics and Clinical Outcomes of Patients With Discordance Between FFR and iFR. JACC. Cardiovascular interventions, 12(20), 2018–2031. doi: 10.1016/j.jcin.2019.06.044
Type
Article
ISSN
1876-7605
Source
https://www.sciencedirect.com/science/article/pii/S1936879819314347?via%3Dihub
DOI
10.1016/j.jcin.2019.06.044
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42377
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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