계명대학교 의학도서관 Repository

Changing Pattern and Safety of Pretransplant Malignancy in Kidney Transplant Recipients

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Author(s)
Tae Hyun BanWoo Yeong ParkKyubok JinSeungyeup HanByung Ha ChungSun Cheol ParkBum Soon ChoiCheol Whee ParkSang-Seob YunYong-Soo KimChul Woo Yang
Keimyung Author(s)
Park, Woo YoungJin, Kyu BokHan, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Kidney research and clinical practice
Issued Date
2019
Volume
38
Issue
4
Keyword
CancerKidney transplant recipientsKidney transplantationMalignancyPretransplant
Abstract
Background:
Cancer rates are increasing not only in the general population but also in patients with end-stage renal disease. We investigated the changing pattern of pretransplant malignancy in kidney transplant recipients over 5 decades.

Methods:
We reviewed 3,748 kidney transplant recipients between 1969 and 2016. We divided patients into three groups (1969–1998, 1999–2006, 2007–2016) based on the era of the cancer screening system used throughout the nation. We analyzed the incidence and pattern of pretransplant malignancy among the three groups. We also evaluated recurrent and de novo malignancy in these patients compared to patients without pretransplant malignancy.

Results:
A total of 72 patients exhibited pretransplant malignancy (1.9%). There were no cases of pretransplant cancer until 1998, but the rate of pretransplant malignancy gradually increased to 1.1% during 1999–2006 and further increased to 4.3% thereafter. The most frequent types of pretransplant malignancy changed from the bladder, liver, and stomach cancers to thyroid cancer and renal cell carcinoma. There were no de novo cases, but there were three cases of recurrent cancer in patients with pretransplant malignancy; the recurrence rate among kidney transplant recipients with pretransplant malignancy was not significantly different from the incidence rate of de novo malignancy among kidney transplant recipients without pretransplant malignancy (4.2% vs. 6.9%, P = 0.48).

Conclusion:
The incidence of pretransplant malignancy in kidney transplantation candidates is gradually increasing, and recent increases were accompanied by changes in cancer types. Pretransplant malignancy may not be a hindrance to kidney transplantation because of the low incidence of posttransplant recurrence and de novo malignancy.
Keimyung Author(s)(Kor)
한승엽
박우영
진규복
Publisher
School of Medicine (의과대학)
Citation
Tae Hyun Ban et al. (2019). Changing Pattern and Safety of Pretransplant Malignancy in Kidney Transplant Recipients. Kidney research and clinical practice, 38(4), 509–516. doi: 10.23876/j.krcp.19.047
Type
Article
ISSN
2211-9140
Source
http://www.krcp-ksn.org/journal/view.html?doi=10.23876/j.krcp.19.047
DOI
10.23876/j.krcp.19.047
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42380
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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