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Peripheral Blood Inflammatory Cytokines in Idiopathic REM Sleep Behavior Disorder

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Author(s)
Ryul KimJin-Sun JunHan-Joon KimKi-Young JungYong-Won ShinTae-Won YangKeun Tae KimTae-Joon KimJung-Ick ByunJun-Sang SunwooBeomseok Jeon,
Keimyung Author(s)
Kim, Keun Tae
Department
Dept. of Neurology (신경과학)
Journal Title
Movement disorders
Issued Date
2019
Volume
34
Issue
11
Keyword
cytokineimmune markersinterleukinperipheral inflammationREM sleep behavior disorder
Abstract
Background:
Although previous research provides insight into the role of neuroinflammation in idiopathic REM sleep behavior disorder, the association of this disorder with peripheral blood inflammatory markers remains unclear.

Objective:
To investigate inflammatory cytokines in plasma samples in patients with idiopathic rapid eye movement sleep behavior disorder and to explore whether these markers are associated with prodromal symptoms of α‐synucleinopathies.

Methods:
We collected plasma from patients with polysomnographically confirmed idiopathic rapid eye movement sleep behavior disorder without parkinsonism or dementia (n = 54) and from healthy controls (n = 56). The following cytokines were measured: interleukin‐1β, interleukin‐2, interleukin‐6, interleukin‐10, and tumor necrosis factor‐α. The idiopathic REM sleep behavior disorder patients underwent sleep, motor, cognitive, olfactory, and autonomic testing.

Results:
The anti‐inflammatory cytokine, interleukin‐10, levels in the idiopathic rapid eye movement sleep behavior disorder group were significantly upregulated compared to the control group (P = 0.022), but this difference did not withstand Bonferroni correction. The other proinflammatory cytokine levels did not differ between the groups. No correlation was found between the cytokine levels and any clinical variable.

Conclusions:
Our data do not provide evidence supporting the role of peripheral inflammation in idiopathic rapid eye movement sleep behavior disorder. However, considering the limited statistical power because of the small sample size, further large‐scale longitudinal studies with a broader spectrum of cytokines are needed to clarify this issue.
Keimyung Author(s)(Kor)
김근태
Publisher
School of Medicine (의과대학)
Citation
Ryul Kim et al. (2019). Peripheral Blood Inflammatory Cytokines in Idiopathic REM Sleep Behavior Disorder. Movement disorders, 34(11), 1739–1744. doi: 10.1002/mds.27841
Type
Article
ISSN
1531-8257
Source
https://onlinelibrary.wiley.com/doi/full/10.1002/mds.27841
DOI
10.1002/mds.27841
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42392
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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