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Increased Frequency of CD4 + CD57 + Senescent T Cells in Patients With Newly Diagnosed Acute Heart Failure: Exploring New Pathogenic Mechanisms With Clinical Relevance

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Author(s)
Jong-Chan YounMin Kyung JungHee Tae YuJi-Soo KwonJeong-Eun KwakSu-Hyung ParkIn-Cheol KimMyung-Soo ParkSun Ki LeeSuk-Won ChoiSeongwoo HanKyu-Hyung RyuSeok-Min KangEui-Cheol Shin
Keimyung Author(s)
Kim, In Cheol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Scientific reports
Issued Date
2019
Volume
9
Issue
1
Abstract
Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 ± 16 years) and 38 healthy control subjects (21 males, mean age 62 ± 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57+ T cells in the CD4+ T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4+CD57+ T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4+CD57− T cell population. Furthermore, the frequency of CD4+CD57+ T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4+CD57+ senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF.
Keimyung Author(s)(Kor)
김인철
Publisher
School of Medicine (의과대학)
Citation
Jong-Chan Youn et al. (2019). Increased Frequency of CD4 + CD57 + Senescent T Cells in Patients With Newly Diagnosed Acute Heart Failure: Exploring New Pathogenic Mechanisms With Clinical Relevance. Scientific reports, 9(1), 12887–12887. doi: 10.1038/s41598-019-49332-5
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-019-49332-5.pdf
DOI
10.1038/s41598-019-49332-5
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42411
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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