Increased Frequency of CD4 + CD57 + Senescent T Cells in Patients With Newly Diagnosed Acute Heart Failure: Exploring New Pathogenic Mechanisms With Clinical Relevance
- Author(s)
- Jong-Chan Youn; Min Kyung Jung; Hee Tae Yu; Ji-Soo Kwon; Jeong-Eun Kwak; Su-Hyung Park; In-Cheol Kim; Myung-Soo Park; Sun Ki Lee; Suk-Won Choi; Seongwoo Han; Kyu-Hyung Ryu; Seok-Min Kang; Eui-Cheol Shin
- Keimyung Author(s)
- Kim, In Cheol
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- Scientific reports
- Issued Date
- 2019
- Volume
- 9
- Issue
- 1
- Abstract
- Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 ± 16 years) and 38 healthy control subjects (21 males, mean age 62 ± 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57+ T cells in the CD4+ T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4+CD57+ T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4+CD57− T cell population. Furthermore, the frequency of CD4+CD57+ T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4+CD57+ senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF.
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