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Diverse roles of arrest defective 1 in cancer development

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Author(s)
Prerna ChaudharyEunyoung HaTam Thuy Lu VoJi Hae Seo
Keimyung Author(s)
Ha, Eun YoungSeo, Ji Hye
Department
Dept. of Biochemistry (생화학)
Journal Title
Archives of Pharmacal Research
Issued Date
2019
Volume
42
Issue
12
Keyword
ARD1AcetyltransferaseAcetylationTumorigenesis
Abstract
Arrest defective 1 is an acetyltransferase that acetylates N-terminal amino acid or internal lysine residues of its target proteins. By acetylating its target proteins, ARD1 plays roles in many cellular activities, including proliferation, differentiation, autophagy, and apoptosis. In recent years, a number of investigations have emerged reporting the dysregulated expression of ARD1 in different types of cancer, including lung, liver, pancreas, breast, prostate, and colon cancer. Furthermore, the expression level of ARD1 in cancer tissues has been correlated with the progression and metastasis of the cancer and the survival of cancer patients. Consequently, mechanistic studies have revealed that ARD1-mediated protein acetylation plays an important role in modulating several cellular events that are important for cancer development, such as cell cycle progression, cell death, and migration. On the basis of this evidence, targeting of ARD1 has been proposed as a promising avenue for the development of novel cancer therapeutics. This review summarizes the biological functions of ARD1 in different types of cancer and provides a deep insight into the biochemical activities of ARD1 during tumor progression.
Keimyung Author(s)(Kor)
하은영
서지혜
Publisher
School of Medicine (의과대학)
Citation
Prerna Chaudhary et al. (2019). Diverse roles of arrest defective 1 in cancer development. Archives of Pharmacal Research, 42(12), 1040–1051. doi: 10.1007/s12272-019-01195-0
Type
Article
ISSN
1976-3786
Source
https://link.springer.com/article/10.1007/s12272-019-01195-0
DOI
10.1007/s12272-019-01195-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42447
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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