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Effectiveness and Safety of Zotarolimus-Eluting Stent (Resolute™ Integrity) in Patients with Diffuse Long Coronary Artery Disease

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Author(s)
Keun-Ho ParkYoungkeun AhnYoung-Youp KohYoung-Jae KiSung Soo KimHyun Kuk KimDong-Hyun ChoiYoung Joon HongJin-Yong HwangDo Hoi KimJay Young RhewJae Kean RyuJong-Seon ParkTae Ho ParkTae Hyun YangSeok Kyu OhBong Ryeol LeeSeung-Uk LeeSang Gon LeeKook Jin ChunJang-Hyun ChoKwang Soo ChaJei Keon ChaeSeung-Ho HurSun Ho HwangHun-Sik ParkDoo-Il Kim
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Circulation Journal
Issued Date
2019
Volume
49
Issue
8
Keyword
Drug-eluting stentsCoronary artery diseaseTreatment outcome
Abstract
Background and Objectives:
Diffuse long coronary artery disease (DLCAD) still has unfavorable clinical outcomes after successful percutaneous coronary intervention (PCI). Therefore, we aimed to evaluate the effectiveness and safety of Resolute™ zotarolimus-eluting stent (R-ZES; Resolute™ Integrity) for patients with DLCAD.

Methods:
From December 2011 to December 2014, 1,011 patients who underwent PCI using R-ZES for CAD with longer than 25 mm lesion were prospectively enrolled from 21 hospitals in Korea. We assessed the clinical outcome of major adverse cardiac events (MACE) defined as the composite of cardiac death, non-fatal myocardial infarction (MI), and clinically-driven target vessel revascularization at 12 months.

Results:
Mean age was 63.8±10.8 years, 701 (69.3%) patients were male, 572 (87.0%) patients had hypertension, 339 (33.8%) patients had diabetes, 549 (54.3%) patients diagnosed with acute MI and 545 (53.9%) patients had multi-vessel disease (MVD). A total of 1,697 stents were implanted into a total of 1,472 lesions. The mean diameter was 3.07±0.38 mm and the length was 28.27±6.97 mm. Multiple overlapping stents were performed in 205 (13.8%) lesions. A 12-month clinical follow-up was available in 1,004 patients (99.3%). The incidences of MACE and definite stent thrombosis at 12-month were 3.0% and 0.3% respectively. On multivariate Cox-regression analysis, multiple overlapping stents implantation, previous congestive heart failure, MVD, and age ≥75 years were independent predictors of one-year MACE.

Conclusions:
Our study shows that R-ZES has an excellent 1-year clinical outcome in Korean patients with DLCAD.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine (의과대학)
Citation
Keun-Ho Park et al. (2019). Effectiveness and Safety of Zotarolimus-Eluting Stent (Resolute™ Integrity) in Patients with Diffuse Long Coronary Artery Disease. Korean Circulation Journal, 49(8), 709–720. doi: 10.4070/kcj.2019.0018
Type
Article
ISSN
1738-5555
Source
https://www.e-kcj.org/search.php?where=aview&id=10.4070/kcj.2019.0018&code=0054KCJ&vmode=FULL
DOI
10.4070/kcj.2019.0018
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42455
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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