계명대학교 의학도서관 Repository

Perinatal Outcomes Following Prolonged Preterm Premature Rupture of Membranes before Limit of Viability - A Single Center Experience

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Author(s)
Na Hyun LeeJae Hyun ParkJin Gon Bae
Keimyung Author(s)
Lee, Na HyunPark, Jae HyunBae, Jin Gon
Department
Dept. of Pediatrics (소아청소년학)
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Perinatology
Issued Date
2019
Volume
30
Issue
4
Keyword
Fetal membranespremature rupturePregnancy maintenancePregnancy complicationsInfant mortality
Abstract
Objective:
To investigate maternal and neonatal outcomes following prolonged preterm premature rupture of membrane (PPROM) before limit of viability in a single center.

Methods:
Thirty-two women with PPROM before 25 weeks' gestation without overt intrauterine infection were administered expectant management. We investigated maternal and neonatal outcomes of pregnancies following PPROM occurring before 25 weeks’ gestation and with latent period (from membrane rupture to delivery) of 7 days or more.

Results:
Median gestational age at membrane rupture was 22.1 weeks. Median latent period was 32 days. Median gestational age at delivery was 26.6 weeks. The incidence of clinical pulmonary hypoplasia and early onset sepsis was 43.5% (10/23) and 21.7% (5/23), respectively. The overall mortality in neonatal intensive care unit (NICU) was 43.5% (10/23). Latent period was negatively correlated with gestational age at membrane rupture (r=-0.501, P=0.015), but not associated with maternal complications. As the length of latent period increased, overall mortality in NICU decreased (relative risk=0.898, P=0.011).

Conclusion:
The expectant management in women with PPROM before 25 weeks' gestation did not induce maternal complications and might help to improve the neonatal outcomes rather than the immediate delivery.
Keimyung Author(s)(Kor)
이나현
박재현
배진곤
Publisher
School of Medicine (의과대학)
Citation
Na Hyun Lee et al. (2019). Perinatal Outcomes Following Prolonged Preterm Premature Rupture of Membranes before Limit of Viability - A Single Center Experience. Perinatology, 30(4), 193–199. doi: 10.14734/PN.2019.30.4.193
Type
Article
ISSN
2508-4895
Source
https://e-kjp.org/DOIx.php?id=10.14734/PN.2019.30.4.193
DOI
10.14734/PN.2019.30.4.193
10.14734/PN.2019.30.4.193
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42462
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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